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MSGene - Gene overview of all published MS-association studies for IL1RN
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 Gene: IL1RN (DIRA; ICIL-1RA; IL-1ra3; IL1F3; IL1RA; IRAP; MGC10430; MVCD4)   View on AlzGene   View on PDGene   View on SZGene
 Protein: interleukin 1 receptor antagonist(IL1RN (IL1F3); OTTHUMP00000203730; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist)
 Chromosome: 2   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Aggelakis, 2009
Greece CL  3  (detail)  351
(66%)
MD132.1 + 9.4
(-)
40.8 + 10.9
(-)
375
(63%)
40.1 + 10.8
(-)
Negative
Aulchenko, 2008
Netherlands (GWAS) CL  1  (detail)  45
(-)
O/M--195
(-)
-Negative
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  1  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Borzani, 2010
Italy CL  3  (detail)  160
(68%)
MD1-40.9 + 8.5
(-)
250
(60%)
-Positive
Crusius, 1995
Overlaps with
Hooper-van Veen, 2003
CL  3  (detail)  57
(70%)
U--65
(-)
-n.a.
de Jong, 2002
Netherlands CL  3  (detail)  75
(60%)
P34 + 9
(-)
50 + 9
(-)
138
(-)
-Negative
de la Concha, 1997
Spain CL  3  (detail)  135
(67%)
P--168
(-)
-Positive
Dincic, 2006
Serbia CL  3  (detail)  162
(62%)
MD129.9 + 9.3
(-)
36.5 + 10.7
(-)
103
(43%)
51.3 + 13.2
(-)
Positive
Epplen, 1997
Germany CL  3  (detail)  358
(66%)
P29
(11-50)
-395
(29%)
38
(23-60)
Negative
Hooper-van Veen, 2003
Netherlands CL  3  (detail)  492
(62%)
P32 + 10
(-)
45 + 11
(-)
228
(-)
-Negative
Huang, 1996
Sweden CL  3  (detail)  132
(-)
U--95
(-)
-Negative
IMSGC, 2007
USA, UK (GWAS) CL,PO  1  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Negative
Kantarci, 2000
USA CL,PO  3  (detail)  122
(75%)
U29.6 + 8.9
(-)
-244
(-)
-Positive
Luomala, 2001
Finland CL  3  (detail)  93
(53%)
P32 + 8.1
(-)
-400
(-)
-Trend
Mann, 2002
UK CL  3  (detail)  444
(69%)
O/M32.1 + 9
(-)
44.5 + 10
(-)
157
(-)
-Trend
Mirowska-Guzel, 2011
Poland CL  1  (detail)  230
(73%)
MD1&229 + 9.9
(-)
38.1 + 10.9
(-)
195
(67%)
40 + 10.1
(-)
Negative
Schrijver, 1999
Overlaps with
Hooper-van Veen, 2003
CL  3  (detail)  148
(58%)
P33.3 + 10
(-)
46
(-)
98
(-)
-n.a.
Sciacca, 1999
Italy CL  3  (detail)  359
(-)
U-38.2 + 11.2
(-)
358
(-)
38.3 + 11.2
(-)
Positive
Semana, 1997
France CL  3  (detail)  77
(-)
U--168
(-)
-Negative
Zhang, 2005
Sweden CL  2  (detail)  672
(72%)
P31.5
(-)
45.6
(15-80)
672
(49%)
54.5
(17-91)
Negative
 Asian
Niino, 2001
Japan CL  3  (detail)  98
(74%)
P26.1 + 8.8
(-)
35.7 + 10.8
(-)
104
(82%)
32.7 + 9.2
(-)
Negative
 Other/Mixed
Amirzargar, 2007
Iran CL  1  (detail)  44
(68%)
P--140
(-)
-Negative
Sarial, 2008
Iran CL  1  (detail)  100
(70%)
U38
(-)
35 + 7
(-)
140
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Feakes, 2000
UK  2  (detail)  536536
(75%)
P25.5
(-)
38
(-)
1072
(50%)
-Negative
Semana, 1997
France  2  (detail)  92-U----Negative
Wansen, 1997
Finland  3  (detail)  106106
(68%)
P-34
(17-52)
212
(50%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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