MSGene

MSGene - Gene overview of all published MS-association studies for IL1RN

Gene:

IL1RN (DIRA; ICIL-1RA; IL-1ra3; IL1F3; IL1RA; IRAP; MGC10430; MVCD4) View on AlzGene View on PDGene View on SZGene

Protein:

interleukin 1 receptor antagonist(IL1RN (IL1F3); OTTHUMP00000203730; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Aggelakis, 2009	Greece	CL	3 (detail)	351 (66%)	MD1	32.1 + 9.4 (-)	40.8 + 10.9 (-)	375 (63%)	40.1 + 10.8 (-)	Negative
Aulchenko, 2008	Netherlands (GWAS)	CL	1 (detail)	45 (-)	O/M	-	-	195 (-)	-	Negative
Baranzini, 2008	USA, Netherlands, Switzerland (GWAS)	CL	1 (detail)	978 (67%)	MD1&2	34 (11-61)	47 (21-69)	883 (66%)	46 (21-69)	Negative
Borzani, 2010	Italy	CL	3 (detail)	160 (68%)	MD1	-	40.9 + 8.5 (-)	250 (60%)	-	Positive
Crusius, 1995	Overlaps with Hooper-van Veen, 2003	CL	3 (detail)	57 (70%)	U	-	-	65 (-)	-	n.a.
de Jong, 2002	Netherlands	CL	3 (detail)	75 (60%)	P	34 + 9 (-)	50 + 9 (-)	138 (-)	-	Negative
de la Concha, 1997	Spain	CL	3 (detail)	135 (67%)	P	-	-	168 (-)	-	Positive
Dincic, 2006	Serbia	CL	3 (detail)	162 (62%)	MD1	29.9 + 9.3 (-)	36.5 + 10.7 (-)	103 (43%)	51.3 + 13.2 (-)	Positive
Epplen, 1997	Germany	CL	3 (detail)	358 (66%)	P	29 (11-50)	-	395 (29%)	38 (23-60)	Negative
Hooper-van Veen, 2003	Netherlands	CL	3 (detail)	492 (62%)	P	32 + 10 (-)	45 + 11 (-)	228 (-)	-	Negative
Huang, 1996	Sweden	CL	3 (detail)	132 (-)	U	-	-	95 (-)	-	Negative
IMSGC, 2007	USA, UK (GWAS)	CL,PO	1 (detail)	931 (75%)	MD1&2	27.8 (10-51)	38.6 (17-59)	2431 (-)	-	Negative
Kantarci, 2000	USA	CL,PO	3 (detail)	122 (75%)	U	29.6 + 8.9 (-)	-	244 (-)	-	Positive
Luomala, 2001	Finland	CL	3 (detail)	93 (53%)	P	32 + 8.1 (-)	-	400 (-)	-	Trend
Mann, 2002	UK	CL	3 (detail)	444 (69%)	O/M	32.1 + 9 (-)	44.5 + 10 (-)	157 (-)	-	Trend
Mirowska-Guzel, 2011	Poland	CL	1 (detail)	230 (73%)	MD1&2	29 + 9.9 (-)	38.1 + 10.9 (-)	195 (67%)	40 + 10.1 (-)	Negative
Schrijver, 1999	Overlaps with Hooper-van Veen, 2003	CL	3 (detail)	148 (58%)	P	33.3 + 10 (-)	46 (-)	98 (-)	-	n.a.
Sciacca, 1999	Italy	CL	3 (detail)	359 (-)	U	-	38.2 + 11.2 (-)	358 (-)	38.3 + 11.2 (-)	Positive
Semana, 1997	France	CL	3 (detail)	77 (-)	U	-	-	168 (-)	-	Negative
Zhang, 2005	Sweden	CL	2 (detail)	672 (72%)	P	31.5 (-)	45.6 (15-80)	672 (49%)	54.5 (17-91)	Negative
Asian
Niino, 2001	Japan	CL	3 (detail)	98 (74%)	P	26.1 + 8.8 (-)	35.7 + 10.8 (-)	104 (82%)	32.7 + 9.2 (-)	Negative
Other/Mixed
Amirzargar, 2007	Iran	CL	1 (detail)	44 (68%)	P	-	-	140 (-)	-	Negative
Sarial, 2008	Iran	CL	1 (detail)	100 (70%)	U	38 (-)	35 + 7 (-)	140 (-)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Feakes, 2000	UK	2 (detail)	536	536 (75%)	P	25.5 (-)	38 (-)	1072 (50%)	-	Negative
Semana, 1997	France	2 (detail)	92	-	U	-	-	-	-	Negative
Wansen, 1997	Finland	3 (detail)	106	106 (68%)	P	-	34 (17-52)	212 (50%)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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