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MSGene - Gene overview of all published MS-association studies for CD40
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 Gene: CD40  (Bp50; CDW40; MGC9013; TNFRSF5; p50)  Entrez Gene    View on AlzGene
 Protein: CD40 molecule, TNF receptor superfamily member 5  (B cell surface antigen CD40; B cell-associated molecule; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 type II isoform; CD40L receptor; nerve growth factor receptor-related B-lymphocyte activation molecule; tumor necrosis factor receptor superfamily, member 5)  ProteinLink
 Chromosome: 20   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
ANZgene, 2009
Australia, New Zealand, UK, USA (GWAS) CL,PO  2  (detail)  1618
(72%)
O/M34.1
(7-67)
-3413
(-)
-Positive
ANZgene, 2009
Australia, New Zealand (REP) CL  2  (detail)  2256
(78%)
O/M34.5
(4-73)
-2310
(-)
-Positive
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  2  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Blanco-Kelly, 2010
Spain CL  1  (detail)  1564
(-)
P30 + 10
(-)
-2948
(-)
-Positive
Buck, 2006
Germany CL  1  (detail)  287
(-)
U30 + 10.9
(12-61)
41 + 11.9
(13-70)
184
(-)
-Negative
IMSGC, 2007
Overlaps with
ANZgene, 2009 (GWAS)
CL,PO  1  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-n.a.
Sanna, 2010
Italy-Sardinia (GWAS) CL  1  (detail)  882
(-)
MD1--872
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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