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MSGene - Gene overview of all published MS-association studies for STAT3
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 Gene: STAT3 (APRF; FLJ20882; HIES; MGC16063)
 Protein: signal transducer and activator of transcription 3 (acute-phase response factor)(DNA-binding protein APRF; acute-phase response factor; signal transducer and activator of transcription 3)
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 5 March 2012
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Aulchenko, 2008
Netherlands (GWAS) CL  1  (detail)  45
(-)
O/M--195
(-)
-Negative
Baranzini, 2008
Overlaps with
Jakkula, 2010 (GeneMSA)
CL  1  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
n.a.
Cenit, 2010
Spain CL  3  (detail)  1540
(-)
P29 + 9
(-)
-1720
(-)
-Negative
Comabella, 2008
Spain (REP) CL  1  (detail)  100
(67%)
P-41.8 + 10.3
(-)
100
(65%)
42.9 + 12.6
(-)
Negative
Comabella, 2008
Spain (GWAS, pooled) CL  1  (detail)  242
(67%)
P-43.5 + 11
(-)
242
(65%)
43.9 + 12.3
(-)
Positive
IMSGC, 2007
USA, UK (GWAS) CL,PO  1  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Negative
IMSGC, 2007
Overlaps with
Jakkula, 2010 (IMSGC)
CL,PO  2  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Negative
IMSGC, 2011
Europe, USA, Australia, New Zealand (WTCCC2-GWAS) CL,PO  1  (detail)  9722
(-)
U32.3
(-)
44.8
(-)
17376
(-)
-Positive
IMSGC, 2011
Netherlands (GeneMSA-GWAS) CL  1  (detail)  230
(74%)
U33
(-)
46
(-)
232
(-)
-Positive
IMSGC, 2011
USA (GeneMSA-GWAS) CL  1  (detail)  486
(76%)
U33
(-)
48
(-)
431
(-)
-Positive
IMSGC, 2011
Switzerland (GeneMSA-GWAS) CL  1  (detail)  253
(74%)
U33
(-)
45
(-)
208
(-)
-Positive
IMSGC, 2011
Australia, New Zealand (ANZ-GWAS) CL  1  (detail)  1618
(72%)
U34
(-)
-1988
(-)
-Positive
IMSGC, 2011
USA (BWH-GWAS) CL  1  (detail)  973
(72%)
U33
(-)
47
(-)
2952
(-)
-Positive
IMSGC, 2011
UK, USA (IMSGC2007-GWAS) CL,PO  1  (detail)  795
(76%)
U28
(-)
41
(-)
1679
(-)
-Positive
Jakkula, 2010
Finland-isolate (GWAS) CL,PO  1  (detail)  68
(-)
O/M--136
(-)
-Positive
Jakkula, 2010
Finland-isolate (Replication) CL,PO  1  (detail)  83
(-)
O/M--365
(-)
-Trend
Jakkula, 2010
Finland-general (Replication) CL  1  (detail)  628
(-)
O/M--668
(-)
-Positive
Jakkula, 2010
Norway (Replication) CL  1  (detail)  607
(-)
O/M--816
(-)
-Positive
Jakkula, 2010
Denmark (Replication) CL  1  (detail)  628
(-)
MD1--1074
(-)
-Positive
Jakkula, 2010
Switzerland (GeneMSA-GWAS) CL  1  (detail)  253
(-)
O/M--208
(-)
-Negative
Jakkula, 2010
Netherlands (GeneMSA-GWAS) CL  1  (detail)  230
(-)
O/M--232
(-)
-Positive
Jakkula, 2010
USA (GeneMSA-GWAS) CL  1  (detail)  486
(-)
O/M--431
(-)
-Positive
Jakkula, 2010
UK (IMSGC-GWAS) CL,PO  1  (detail)  453
(-)
O/M--2950
(-)
-Negative
Jakkula, 2010
USA (IMSGC-GWAS) CL  1  (detail)  342
(-)
O/M--1679
(-)
-Negative
Jakkula, 2010
USA (BWH-GWAS) CL  1  (detail)  860
(-)
O/M--1720
(-)
-Positive
Lill, 2011
Germany CL  2  (detail)  2932
(71%)
O/M-41 + 11.4
(-)
2972
(60%)
42 + 16.9
(-)
Positive
Sanna, 2010
Italy-Sardinia (GWAS) CL  1  (detail)  882
(-)
MD1--872
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Bergkvist, 2004
Sweden  1  (detail)  2757
(65%)
P--83
(46%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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