Multiple Sclerosis Discovery Forum
  News and Future Directions
  Papers
  Forums
  Professional Resources
  Research Resources
MSGene - Gene overview of all published MS-association studies for CD58
Back Search Methods Disclaimer Credits
 Gene: CD58  (RP5-1086K13.2; FLJ23181; FLJ43722; LFA-3; LFA3)  Entrez Gene
 Protein: CD58 molecule  (CD58 antigen, (lymphocyte function-associated antigen 3); surface glycoprotein LFA-3)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011 ;  

***Note that content for MSGene is still being curated and that most currently displayed pages (including this page) contain preliminary summaries and are still incomplete.***

Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
ANZgene, 2009
Overlaps with
IMSGC, 2011 (ANZ-GWAS)
CL,PO  1  (detail)  1618
(72%)
O/M34.1
(7-67)
-3413
(-)
-n.a.
ANZgene, 2009
Overlaps with
IMSGC, 2011 (Australia, New Zealand)
CL  1  (detail)  2256
(78%)
O/M34.5
(4-73)
-2310
(-)
-n.a.
Aulchenko, 2008
Netherlands (GWAS) CL  1  (detail)  45
(-)
O/M--195
(-)
-Negative
Baranzini, 2008
Overlaps with
IMSGC, 2011 (GeneMSA-GWAS)
CL  8  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Brynedal, 2009
Sweden CL  9  (detail)  1077
(-)
U--1217
(-)
-Positive
De Jager, 2009
Belgium CL  2  (detail)  368
(63%)
MD135
(10-65)
51
(-)
372
(-)
-Negative
De Jager, 2009
Finland CL  2  (detail)  715
(71%)
MD1--727
(-)
-Negative
De Jager, 2009
UK CL  2  (detail)  961
(73%)
MD133
(13-60)
46
(-)
2466
(-)
-Negative
De Jager, 2009
USA (CA) CL  2  (detail)  1557
(-)
MD1--855
(-)
-Positive
De Jager, 2009
Overlaps with
IMSGC, 2011 (BWH)
CL  30  (detail)  707
(75%)
MD133
(10-69)
45
(-)
--Positive
D'Netto, 2009
Canada CL  1  (detail)  43
(-)
U--182
(-)
-Positive
Hoppenbrouwers, 2008
Overlaps with
Aulchenko, 2008
CL  1  (detail)  46
(72%)
U33 + 11
(-)
-194
(-)
-n.a.
Hoppenbrouwers, 2009
Netherlands (outbred) CL  1  (detail)  490
(-)
O/M--426
(-)
-Positive
Hoppenbrouwers, 2009
Overlaps with
Aulchenko, 2008
CL  1  (detail)  45
(-)
O/M--195
(-)
-n.a.
IMSGC, 2007
USA, UK (GWAS) CL,PO  2  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Positive
IMSGC, 2007
Overlaps with
De Jager, 2009 (UK)
CL  1  (detail)  928
(73%)
MD1&232.6
(13-60)
45.1
(17-79)
1475
(-)
-n.a.
IMSGC, 2007
Overlaps with
De Jager, 2009 (USA)
CL  1  (detail)  1394
(73%)
MD1&233.1
(3-69)
45.4
(18-74)
1512
(-)
-n.a.
IMSGC, 2011
Europe, USA, Australia, New Zealand (WTCCC2-GWAS) CL,PO  1  (detail)  9722
(-)
U32.3
(-)
44.8
(-)
17376
(-)
-Positive
IMSGC, 2011
Netherlands (GeneMSA-GWAS) CL  1  (detail)  230
(74%)
U33
(-)
46
(-)
232
(-)
-Negative
IMSGC, 2011
USA (GeneMSA-GWAS) CL  1  (detail)  486
(76%)
U33
(-)
48
(-)
431
(-)
-Negative
IMSGC, 2011
Switzerland (GeneMSA-GWAS) CL  1  (detail)  253
(74%)
U33
(-)
45
(-)
208
(-)
-Negative
IMSGC, 2011
Australia, New Zealand (ANZ-GWAS) CL  1  (detail)  1618
(72%)
U34
(-)
-1988
(-)
-Negative
IMSGC, 2011
USA (BWH-GWAS) CL  1  (detail)  973
(72%)
U33
(-)
47
(-)
2952
(-)
-Negative
IMSGC, 2011
UK, USA (IMSGC2007-GWAS) CL,PO  1  (detail)  795
(76%)
U28
(-)
41
(-)
1679
(-)
-Negative
Perera, 2009
Overlaps with
Rubio, 2008
CL  1  (detail)  1146
(-)
O/M--1309
(-)
-Positive
Rubio, 2008
Australia CL  1  (detail)  1146
(75%)
O/M32
(7-67)
-1309
(-)
-Positive
Sanna, 2010
Italy-Sardinia (GWAS) CL  1  (detail)  882
(-)
MD1--872
(-)
-Positive
 African Descent
Johnson, 2009
USA CL  2  (detail)  918
(79%)
MD1--656
(71%)
-Negative
 Other/Mixed
Pandit, 2010
India CL  1  (detail)  197
(48%)
MD130 + 5.6
(-)
35.4 + 3.2
(-)
197
(49%)
31.2 + 4.4
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
De Jager, 2009
Australia  2  (detail)  372-MD133
(7-55)
42
(-)
--Positive
De Jager, 2009
Belgium  2  (detail)  134-MD128
(9-45)
38
(-)
--Positive
De Jager, 2009
USA, UK  14  (detail)  1278-MD1----Positive
D'Netto, 2009
Overlaps with
D'Netto, 2009 (CC)
 1  (detail)  43211
(-)
U----Positive
Hoppenbrouwers, 2009
Canada  1  (detail)   1318
(-)
O/M--1507
(-)
-Positive
IMSGC, 2007
Overlaps with
De Jager, 2009 (UK)
 1  (detail)  380380
(75%)
MD1&227.4
(10-53)
37.4
(17-58)
--n.a.
IMSGC, 2007
Overlaps with
De Jager, 2009 (USA)
 1  (detail)  229229
(79%)
MD1&231.1
(9-51)
39.4
(19-58)
--n.a.
IMSGC, 2007
Overlaps with
IMSGC, 2007 (UK-GWAS, CC)
 1  (detail)  453453
(75%)
MD1&226.5
(10-48)
38.2
(19-59)
--Positive
IMSGC, 2007
Overlaps with
IMSGC, 2007 (USA-GWAS, CC)
 1  (detail)  478478
(74%)
MD1&229
(11-51)
39
(17-57)
--Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
Print this page
Email this page
MSDF RSS

Text size
Share & Bookmark
MSGene Recent Updates
MSGene Top Results
Top Results Details
1. HLA-DRB1
2. IL2RA
3. IL7R
4. TAGAP
5. CLEC16A
6. EVI5
7. GWA_16q24.1
8. GWA_5p13.1
9. TTC34
10. AHI1   
[see more]
MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
Copyright © 2017 Biomedical Research Forum LLC Disclaimer Copyright