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MSGene - Gene overview of all published MS-association studies for IL7R
Gene:
IL7R
(ILRA; IL7R; IL-7R-alpha; CDW127; IL7RA; CD127)
Protein:
interleukin 7 receptor
Chromosome:
5
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 25 November 2011
1. Case-Control Studies (by ethnic group)
MS Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Caucasian
Akkad, 2009
Germany
CL
5
(detail)
1319
(68%)
P
31.6
(-)
-
908
(47%)
46.7
(-)
Positive
Alcina, 2008
Spain
CL
1
(detail)
599
(-)
P
-
-
594
(-)
-
Positive
ANZgene, 2009
Overlaps with
IMSGC, 2008 (Australia, New Zealand, USA, UK)
CL,PO
2
(detail)
1618
(72%)
O/M
34.1
(7-67)
-
3413
(-)
-
n.a.
ANZgene, 2009
Australia, New Zealand (REP)
CL
2
(detail)
2256
(78%)
O/M
34.5
(4-73)
-
2310
(-)
-
Negative
Aulchenko, 2008
Netherlands (GWAS)
CL
2
(detail)
45
(-)
O/M
-
-
195
(-)
-
Negative
Ban, 2009
Overlaps with
IMSGC, 2008 (Belgium)
CL
1
(detail)
368
(-)
O/M
-
-
374
(-)
-
n.a.
Ban, 2009
Overlaps with
IMSGC, 2008 (Norway)
CL
1
(detail)
638
(-)
O/M
32
(-)
46.3
(-)
1026
(-)
-
n.a.
Ban, 2009
Overlaps with
Gregory, 2007 (UK)
CL
1
(detail)
475
(-)
O/M
-
-
479
(-)
-
n.a.
Ban, 2009
Overlaps with
IMSGC, 2008 (USA)
CL
1
(detail)
1222
(-)
O/M
-
-
543
(-)
-
n.a.
Ban, 2009
Overlaps with
IMSGC, 2008 (UK)
CL
1
(detail)
1531
(-)
O/M
31
(-)
44
(-)
561
(-)
-
n.a.
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS)
CL
5
(detail)
978
(67%)
MD1&2
34
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Booth, 2005
Australia
CL
1
(detail)
363
(-)
O/M
-
-
182
(-)
-
Positive
Broux, 2010
Belgium
CL
4
(detail)
65
(-)
U
34.4
(-)
44.7 + 11.2
(20-68)
33
(-)
33.2 + 10.7
(21-55)
Negative
D'Netto, 2009
Canada
CL
1
(detail)
43
(-)
U
-
-
182
(-)
-
Negative
Gregory, 2007
Overlaps with
IMSGC, 2008 (UK, Belgium)
CL
1
(detail)
1077
(69%)
U
33.6
(10-62)
50
(-)
2725
(50%)
44.6
(24-61)
Positive
Gregory, 2007
Overlaps with
IMSGC, 2008 (USA)
CL
7
(detail)
438
(68%)
U
31.9
(11-60)
41.8
(-)
479
(66%)
41.6
(21-60)
Positive
Hoe, 2010
Australia (Westmead)
CL
4
(detail)
810
(-)
U
-
-
991
(-)
-
Positive
Hoppenbrouwers, 2008
Overlaps with
Hoppenbrouwers, 2009
CL
1
(detail)
46
(72%)
P
33 + 11
(-)
-
194
(-)
-
n.a.
Hoppenbrouwers, 2009
Netherlands (isolated)
CL
1
(detail)
45
(-)
O/M
-
-
195
(-)
-
Negative
Hoppenbrouwers, 2009
Netherlands (outbred)
CL
1
(detail)
490
(-)
O/M
-
-
426
(-)
-
Negative
IMSGC, 2007
Overlaps with
IMSGC, 2008 (UK)
CL
1
(detail)
928
(73%)
MD1&2
32.6
(13-60)
45.1
(17-79)
1475
(-)
-
n.a.
IMSGC, 2007
Overlaps with
IMSGC, 2008 (USA, UK)
CL,PO
3
(detail)
931
(75%)
MD1&2
27.8
(10-51)
38.6
(17-59)
2431
(-)
-
n.a.
IMSGC, 2007
Overlaps with
IMSGC, 2008 (USA)
CL
1
(detail)
1394
(73%)
MD1&2
33.1
(3-69)
45.4
(18-74)
1512
(-)
-
n.a.
IMSGC, 2008
Overlaps with
Lundmark, 2007 (Sweden)
CL
1
(detail)
1100
(-)
U
-
-
1251
(-)
-
n.a.
IMSGC, 2008
Overlaps with
Kallio, 2009 (Finland)
CL
1
(detail)
561
(-)
U
-
-
1017
(-)
-
n.a.
IMSGC, 2008
UK
CL
1
(detail)
2323
(-)
U
-
-
2960
(-)
-
Positive
IMSGC, 2008
USA
CL
1
(detail)
1394
(-)
U
-
-
2466
(-)
-
Positive
IMSGC, 2008
Denmark
CL
1
(detail)
504
(-)
U
-
-
541
(-)
-
Positive
IMSGC, 2008
Overlaps with
ANZgene, 2009 (Australia)
CL
1
(detail)
472
(-)
U
-
-
424
(-)
-
n.a.
IMSGC, 2008
Belgium
CL
1
(detail)
405
(-)
U
-
-
462
(-)
-
Positive
IMSGC, 2008
Germany
CL
1
(detail)
206
(-)
U
-
-
605
(-)
-
Negative
IMSGC, 2008
Italy
CL
1
(detail)
863
(-)
U
-
-
775
(-)
-
Positive
IMSGC, 2008
Overlaps with
Sanna, 2010
CL
1
(detail)
909
(-)
U
-
-
576
(-)
-
n.a.
IMSGC, 2008
Overlaps with
Hoppenbrouwers, 2009 (Netherlands)
CL
1
(detail)
46
(-)
U
-
-
194
(-)
-
n.a.
IMSGC, 2008
UK (Northern Ireland)
CL
1
(detail)
683
(-)
U
-
-
532
(-)
-
Negative
IMSGC, 2008
Norway
CL
1
(detail)
738
(-)
U
-
-
1027
(-)
-
Positive
IMSGC, 2008
Spain
CL
1
(detail)
815
(-)
U
-
-
786
(-)
-
Negative
Kallio, 2009
Finland (isolate)
PO
4
(detail)
197
(-)
O/M
-
-
433
(-)
-
Positive
Kallio, 2009
Overlaps with
Lundmark, 2007 (Sweden)
CL
4
(detail)
651
(-)
O/M
-
-
651
(-)
-
n.a.
Kallio, 2009
Finland (other)
CL
4
(detail)
725
(-)
O/M
-
-
959
(-)
-
Positive
Lundmark, 2007
Sweden,Norway,Denmark,Finland
CL
3
(detail)
1820
(72%)
O/M
-
46.4
(-)
2634
(53%)
38.6
(-)
Positive
Lundmark, 2007
Sweden
CL
11
(detail)
1210
(73%)
O/M
-
-
1234
(63%)
45.6
(-)
Positive
O'Doherty, 2008
USA
CL,PO
8
(detail)
208
(-)
U
-
-
413
(-)
-
Positive
O'Doherty, 2008
Overlaps with
IMSGC, 2008 (Northern Ireland)
CL
8
(detail)
463
(-)
U
-
-
532
(-)
-
Negative
Rubio, 2008
Overlaps with
ANZgene, 2009 (GWAS)
CL
1
(detail)
1146
(75%)
O/M
32
(7-67)
-
1309
(-)
-
n.a.
Sanna, 2010
Italy-Sardinia (GWAS)
CL
1
(detail)
882
(-)
MD1
-
-
872
(-)
-
Negative
Sombekke, 2011
Overlaps with
Baranzini, 2008 (Netherlands)
CL
1
(detail)
697
(64%)
O/M
32.1
(-)
-
174
(56%)
46.5
(-)
Positive
Stankovic, 2010
Serbia
CL
1
(detail)
375
(-)
O/M
-
-
227
(-)
-
Negative
Stankovic, 2010
Croatia
CL
1
(detail)
161
(-)
O/M
-
-
261
(-)
-
Negative
Stankovic, 2010
Slovenia
CL
1
(detail)
142
(-)
O/M
-
-
109
(-)
-
Negative
Teutsch, 2003
Overlaps with
Booth, 2005
CL
3
(detail)
176
(-)
P
-
-
176
(-)
-
Trend
Weber, 2008
Overlaps with
IMSGC, 2008 (Germany)
CL
1
(detail)
206
(63%)
O/M
-
37.8
(19-59)
605
(-)
-
n.a.
WTCCC, 2007
Overlaps with
IMSGC, 2008 (UK)
CL,PO
4
(detail)
994
(72%)
O/M
30.3
(10-60)
43.8
(17-79)
1466
(50%)
-
Positive
Zhang, 2005
Sweden
CL
5
(detail)
672
(72%)
P
31.5
(-)
45.6
(15-80)
672
(49%)
54.5
(17-91)
Positive
African Descent
Johnson, 2009
USA
CL
1
(detail)
918
(79%)
MD1
-
-
656
(71%)
-
Negative
Other/Mixed
Heidari, 2010
Iran
CL
4
(detail)
100
(78%)
O/M
28.8
(-)
-
100
(68%)
-
Positive
Pandit, 2010
India
CL
1
(detail)
197
(48%)
MD1
30 + 5.6
(-)
35.4 + 3.2
(-)
197
(49%)
31.2 + 4.4
(-)
Positive
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Caucasian
Ban, 2009
Australia
1
(detail)
372
-
O/M
32.9
(-)
47.2
(-)
-
-
Negative
Ban, 2009
USA
1
(detail)
875
-
O/M
-
-
-
-
Positive
Ban, 2009
Overlaps with
Gregory, 2007 (Belgium)
1
(detail)
113
-
O/M
-
-
-
-
n.a.
Ban, 2009
Overlaps with
Gregory, 2007 (UK)
1
(detail)
693
-
O/M
-
-
-
-
n.a.
Booth, 2005
Australia
1
(detail)
216
-
O/M
-
-
-
-
Positive
D'Netto, 2009
Overlaps with
D'Netto, 2009 (CC)
1
(detail)
43
211
(-)
U
-
-
-
-
n.a.
Gregory, 2007
UK, Belgium
1
(detail)
1338
1338
(74%)
U
27.1
(9-53)
37.9
(-)
2676
(50%)
-
Positive
Gregory, 2007
Overlaps with
Ban, 2009 (USA)
14
(detail)
760
1055
(74%)
U
29.8
(3-63)
43.4
(-)
-
-
Positive
Hoppenbrouwers, 2009
Canada
1
(detail)
1318
(-)
O/M
-
-
1507
(-)
-
Positive
IMSGC, 2007
Overlaps with
Gregory, 2007 (UK)
1
(detail)
380
380
(75%)
MD1&2
27.4
(10-53)
37.4
(17-58)
-
-
n.a.
IMSGC, 2007
Overlaps with
IMSGC, 2008 (USA)
1
(detail)
229
229
(79%)
MD1&2
31.1
(9-51)
39.4
(19-58)
-
-
n.a.
IMSGC, 2007
Overlaps with
IMSGC, 2007 (UK-GWAS, CC)
1
(detail)
453
453
(75%)
MD1&2
26.5
(10-48)
38.2
(19-59)
-
-
Positive
IMSGC, 2007
Overlaps with
IMSGC, 2007 (USA-GWAS, CC)
1
(detail)
478
478
(74%)
MD1&2
29
(11-51)
39
(17-57)
-
-
Positive
IMSGC, 2008
Overlaps with
Gregory, 2007 (Belgium)
1
(detail)
114
-
U
-
-
-
-
n.a.
IMSGC, 2008
Overlaps with
Gregory, 2007 (UK)
1
(detail)
833
-
U
-
-
-
-
n.a.
IMSGC, 2008
Finland
1
(detail)
254
-
U
-
-
-
-
Negative
IMSGC, 2008
Overlaps with
Ban, 2009 (USA)
1
(detail)
707
-
U
-
-
-
-
n.a.
IMSGC, 2008
France
1
(detail)
540
-
U
-
-
-
-
Negative
IMSGC, 2008
Italy (Sardinia)
1
(detail)
363
-
U
-
-
-
-
Negative
Ramagopalan, 2009
Overlaps with
Hoppenbrouwers, 2009
1
(detail)
600
1193
(-)
U
-
-
1553
(-)
-
n.a.
Riise Stensland, 2005
Finland
1
(detail)
444
497
(-)
P
-
-
-
-
Negative
Teutsch, 2003
Overlaps with
Booth, 2005
1
(detail)
186
-
P
-
-
-
-
n.a.
Weber, 2008
Overlaps with
IMSGC, 2008 (France)
1
(detail)
540
540
(70%)
O/M
26.5
(9-47)
41.7
(19-67)
1080
(50%)
-
n.a.
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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