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MSGene - Gene overview of all published MS-association studies for HLA-DRB1
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 Gene: HLA-DRB1  (XXbac-BPG161M6.1; DRB1; DRw10; FLJ75017; FLJ76359; HLA-DR1B; HLA-DRB; HLA-DRB1*; SS1)  Entrez Gene    View on PDGene
 Protein: major histocompatibility complex, class II, DR beta 1  (Clone P2-beta-4; DR-1; DR-16; DR-5; DR-8; DR1; DR16; DR5; DR8; DRw11; DRw8; HLA class II antigen beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1-1 beta chain; HLA class II histocompatibility antigen, DRB1-10 beta chain; HLA class II histocompatibility antigen, DRB1-11 beta chain; HLA class II histocompatibility antigen, DRB1-16 beta chain; HLA class II histocompatibility antigen, DRB1-3 chain; HLA class II histocompatibility antigen, DRB1-8 beta chain; HLA-DR-beta 1; MHC class I antigen DRB1*1; MHC class I antigen DRB1*16; MHC class I antigen DRB1*8; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class II antigen DRB1*10; MHC class II antigen DRB1*11; MHC class II antigen DRB1*3; MHC class II antigen HLA-DR13; cell surface glycoprotein; clone P2-beta-3; human leucocyte antigen DRB1; leucocyte antigen DR beta 1 chain; leucocyte antigen DRB1; lymphocyte antigen DRB1)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Hoppenbrouwers, 2008
Overlaps with
Hoppenbrouwers, 2009
CL  1  (detail)  46
(72%)
U33 + 11
(-)
-194
(-)
-n.a.
Hoppenbrouwers, 2009
Netherlands (isolated) CL  1  (detail)  45
(-)
O/M--195
(-)
-Positive
Hoppenbrouwers, 2009
Netherlands (outbred) CL  1  (detail)  490
(-)
O/M--426
(-)
-Positive
IMSGC, 2007
UK CL  1  (detail)  928
(73%)
MD1&232.6
(13-60)
45.1
(17-79)
1475
(-)
-Positive
IMSGC, 2007
USA CL  1  (detail)  1394
(73%)
MD1&233.1
(3-69)
45.4
(18-74)
1512
(-)
-Positive
Rubio, 2008
Australia CL  1  (detail)  1146
(75%)
O/M32
(7-67)
-1309
(-)
-Positive
Sanna, 2010
Italy-Sardinia (GWAS) CL  1  (detail)  882
(-)
MD1--872
(-)
-Negative
Zivkovic, 2009
Serbia CL  1  (detail)  269
(61%)
MD1298 + 87
(-)
363 + 105
(-)
223
(48%)
432 + 116
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Hoppenbrouwers, 2009
Canada  1  (detail)   1318
(-)
O/M--1507
(-)
-Positive
IMSGC, 2007
UK  1  (detail)  380380
(75%)
MD1&227.4
(10-53)
37.4
(17-58)
--Positive
IMSGC, 2007
USA  1  (detail)  229229
(79%)
MD1&231.1
(9-51)
39.4
(19-58)
--Positive
IMSGC, 2007
Overlaps with
IMSGC, 2007 (UK-GWAS, CC)
 1  (detail)  453453
(75%)
MD1&226.5
(10-48)
38.2
(19-59)
--Positive
IMSGC, 2007
Overlaps with
IMSGC, 2007 (USA-GWAS, CC)
 1  (detail)  478478
(74%)
MD1&229
(11-51)
39
(17-57)
--Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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