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MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs3135388

Polymorphism:

rs3135388 (tSNP_HLA-DRB1*1501)

Gene:

HLA-DRB1 (XXbac-BPG161M6.1; DRB1; DRw10; FLJ75017; FLJ76359; HLA-DR1B; HLA-DRB; HLA-DRB1*; SS1)

View on PDGene

Protein:

major histocompatibility complex, class II, DR beta 1 (Clone P2-beta-4; DR-1; DR-16; DR-5; DR-8; DR1; DR16; DR5; DR8; DRw11; DRw8; HLA class II antigen beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1-1 beta chain; HLA class II histocompatibility antigen, DRB1-10 beta chain; HLA class II histocompatibility antigen, DRB1-11 beta chain; HLA class II histocompatibility antigen, DRB1-16 beta chain; HLA class II histocompatibility antigen, DRB1-3 chain; HLA class II histocompatibility antigen, DRB1-8 beta chain; HLA-DR-beta 1; MHC class I antigen DRB1*1; MHC class I antigen DRB1*16; MHC class I antigen DRB1*8; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class II antigen DRB1*10; MHC class II antigen DRB1*11; MHC class II antigen DRB1*3; MHC class II antigen HLA-DR13; cell surface glycoprotein; clone P2-beta-3; human leucocyte antigen DRB1; leucocyte antigen DR beta 1 chain; leucocyte antigen DRB1; lymphocyte antigen DRB1)

Chromosome:

6 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		A-Allele (frequency)	G-Allele (frequency)	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian	4	MS CTR	0.29 0.15	0.71 0.85	164 (0.084) 49 (0.023)	790 (0.405) 552 (0.256)	996 (0.511) 1552 (0.721)
Total	4	MS CTR	0.29 0.15	0.71 0.85	164 (0.084) 49 (0.023)	790 (0.405) 552 (0.256)	996 (0.511) 1552 (0.721)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism *rs3135388 (tSNP_HLA-DRB11501)**

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs3135388i (tSNP_HLA-DRB1*1501)

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