Multiple Sclerosis Discovery Forum
  News and Future Directions
  Papers
  Forums
  Professional Resources
  Research Resources
MSGene - Gene overview of all published MS-association studies for TYK2
Back Search Methods Disclaimer Credits
 Gene: TYK2  (JTK1)  Entrez Gene
 Protein: tyrosine kinase 2   ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 23 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Ban, 2009
Belgium CL  1  (detail)  368
(-)
O/M--374
(-)
-Negative
Ban, 2009
Norway CL  1  (detail)  638
(-)
O/M32
(-)
46.3
(-)
1026
(-)
-Negative
Ban, 2009
USA CL  1  (detail)  1222
(-)
O/M--543
(-)
-Positive
Ban, 2009
UK (I) CL  1  (detail)  475
(-)
O/M--479
(-)
-Positive
Ban, 2009
UK (II) CL  1  (detail)  1531
(-)
O/M31
(-)
44
(-)
561
(-)
-Negative
Couturier, 2011
France CL  1  (detail)  726
(75%)
O/M27.7
(15-44)
38.7
(24-56)
522
(49%)
42.6
(21-62)
Positive
Mero, 2009
Denmark CL  1  (detail)  1112
(-)
O/M--1147
(-)
-Negative
Mero, 2009
Finland CL  1  (detail)  810
(-)
O/M--1079
(-)
-Trend
Mero, 2009
Norway CL  1  (detail)  1396
(-)
O/M--2064
(-)
-Trend
Mero, 2009
Sweden CL  1  (detail)  2111
(-)
O/M--1877
(-)
-Positive
WTCCC, 2007
UK (GWAS) CL,PO  1  (detail)  994
(72%)
O/M30.3
(10-60)
43.8
(17-79)
1466
(50%)
-Negative
Zuvich, 2010
USA, UK (I) CL,PO  1  (detail)  1479
(-)
MD1--1482
(-)
-Positive
Zuvich, 2010
USA, UK (II) CL,PO  1  (detail)  2397
(-)
MD1--2434
(-)
-Positive
 African Descent
Johnson, 2009
USA CL  2  (detail)  918
(79%)
MD1--656
(71%)
-Positive
 Other/Mixed
Pandit, 2010
India CL  1  (detail)  197
(48%)
MD130 + 5.6
(-)
35.4 + 3.2
(-)
197
(49%)
31.2 + 4.4
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Ban, 2009
Australia  1  (detail)  372-O/M32.9
(-)
47.2
(-)
--Negative
Ban, 2009
Belgium  1  (detail)  113-O/M----Negative
Ban, 2009
USA  1  (detail)  875-O/M----Positive
Ban, 2009
UK (I)  1  (detail)  693-O/M----Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
Print this page
Email this page
MSDF RSS

Text size
Share & Bookmark
MSGene Recent Updates
MSGene Top Results
Top Results Details
1. HLA-DRB1
2. IL2RA
3. IL7R
4. TAGAP
5. CLEC16A
6. EVI5
7. GWA_16q24.1
8. GWA_5p13.1
9. TTC34
10. AHI1   
[see more]
MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
Copyright © 2017 Biomedical Research Forum LLC Disclaimer Copyright