MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs34536443

Polymorphism:

rs34536443

Gene:

TYK2 (JTK1)

Protein:

tyrosine kinase 2

Chromosome:

19 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		C-Allele (frequency)	G-Allele (frequency)	C/C (frequency)	C/G (frequency)	G/G (frequency)
Caucasian	9	MS CTR	0.04 0.05	0.97 0.96	8 (0.001) 21 (0.002)	654 (0.068) 784 (0.086)	8963 (0.931) 8323 (0.912)
Other/Mixed	1	MS CTR	0.01 0.01	0.99 0.99	0 (0.000) 0 (0.000)	3 (0.015) 5 (0.025)	194 (0.985) 192 (0.975)
Total	10	MS CTR	0.03 0.05	0.97 0.96	8 (0.001) 21 (0.002)	657 (0.067) 789 (0.085)	9157 (0.932) 8515 (0.913)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs34536443

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs12720222
rs2304256

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