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MSGene - Gene overview of all published MS-association studies for CLEC16A
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 Gene: CLEC16A  (Gop-1; KIAA0350; MGC111457)  Entrez Gene
 Protein: C-type lectin domain family 16, member A   ProteinLink
 Chromosome: 16   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
ANZgene, 2009
Australia, New Zealand, UK, USA (GWAS) CL,PO  1  (detail)  1618
(72%)
O/M34.1
(7-67)
-3413
(-)
-Positive
Aulchenko, 2008
Netherlands (GWAS) CL  2  (detail)  45
(-)
O/M--195
(-)
-Negative
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  4  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
D'Netto, 2009
Canada CL  1  (detail)  43
(-)
U--182
(-)
-Negative
Hoppenbrouwers, 2008
Overlaps with
Aulchenko, 2008
CL  1  (detail)  46
(72%)
P33 + 11
(-)
-194
(-)
-n.a.
Hoppenbrouwers, 2009
Overlaps with
Aulchenko, 2008
CL  1  (detail)  45
(-)
O/M--195
(-)
-n.a.
Hoppenbrouwers, 2009
Netherlands (outbred) CL  1  (detail)  490
(-)
O/M--426
(-)
-Positive
IMSGC, 2007
USA, UK (GWAS) CL,PO  2  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Positive
IMSGC, 2007
UK CL  1  (detail)  928
(73%)
MD1&232.6
(13-60)
45.1
(17-79)
1475
(-)
-Positive
IMSGC, 2007
USA CL  1  (detail)  1394
(73%)
MD1&233.1
(3-69)
45.4
(18-74)
1512
(-)
-Positive
IMSGC, 2009
Belgium CL  1  (detail)  398
(-)
MD1&2-47
(-)
461
(-)
-Trend
IMSGC, 2009
Overlaps with
Mero, 2010 (Norway)
CL  1  (detail)  644
(-)
MD1&232
(-)
46.3
(-)
1023
(-)
-n.a.
IMSGC, 2009
Sweden CL  1  (detail)  1014
(-)
MD1&231
(-)
45.6
(-)
1173
(-)
-Positive
IMSGC, 2009
UK CL  1  (detail)  2370
(-)
MD1&2-44.2
(-)
7078
(-)
-Positive
IMSGC, 2009
USA CL  1  (detail)  1311
(-)
MD1&2-44.3
(-)
561
(-)
-Negative
IMSGC, 2011
Europe, USA, Australia, New Zealand (WTCCC2-GWAS) CL,PO  1  (detail)  9722
(-)
U32.3
(-)
44.8
(-)
17376
(-)
-Positive
IMSGC, 2011
Netherlands (GeneMSA-GWAS) CL  1  (detail)  230
(74%)
U33
(-)
46
(-)
232
(-)
-Positive
IMSGC, 2011
USA (GeneMSA-GWAS) CL  1  (detail)  486
(76%)
U33
(-)
48
(-)
431
(-)
-Positive
IMSGC, 2011
Switzerland (GeneMSA-GWAS) CL  1  (detail)  253
(74%)
U33
(-)
45
(-)
208
(-)
-Positive
IMSGC, 2011
Australia, New Zealand (ANZ-GWAS) CL  1  (detail)  1618
(72%)
U34
(-)
-1988
(-)
-Positive
IMSGC, 2011
USA (BWH-GWAS) CL  1  (detail)  973
(72%)
U33
(-)
47
(-)
2952
(-)
-Positive
IMSGC, 2011
UK, USA (IMSGC2007-GWAS) CL,PO  1  (detail)  795
(76%)
U28
(-)
41
(-)
1679
(-)
-Positive
Martinez, 2009
Spain CL  2  (detail)  435
(60%)
P--550
(-)
-Positive
Mero, 2010
Norway (I) PO  49  (detail)  807
(-)
O/M--1027
(-)
-Positive
Mero, 2010
Norway (II) CL,PO  6  (detail)  1206
(-)
O/M--2064
(-)
-Positive
Mero, 2010
Overlaps with
IMSGC, 2007 (UK)
CL,PO  6  (detail)  1102
(-)
O/M--1980
(-)
-Positive
Nischwitz, 2010
Germany CL  31  (detail)  603
(65%)
O/M-39.1
(16-75)
825
(54%)
50.9
(18-75)
Positive
Perera, 2009
Overlaps with
Rubio, 2008
CL  7  (detail)  1146
(-)
O/M--1309
(-)
-Positive
Rubio, 2008
Australia CL  1  (detail)  1146
(75%)
O/M32
(7-67)
-1309
(-)
-Positive
Sanna, 2010
Italy-Sardinia (GWAS) CL  1  (detail)  882
(-)
MD1--872
(-)
-Negative
Zoledziewska, 2008
Italy (Sardinia) CL  1  (detail)  1088
(68%)
MD131.3 + 10
(5-60)
-712
(-)
-Positive
 African Descent
Johnson, 2009
USA CL  2  (detail)  918
(79%)
MD1--656
(71%)
-Positive
 Other/Mixed
Pandit, 2010
India CL  2  (detail)  197
(48%)
MD130 + 5.6
(-)
35.4 + 3.2
(-)
197
(49%)
31.2 + 4.4
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
D'Netto, 2009
Overlaps with
D'Netto, 2009 (CC)
 1  (detail)  43211
(-)
U----Positive
Hoppenbrouwers, 2009
Canada  1  (detail)   1318
(-)
O/M--1507
(-)
-Positive
IMSGC, 2007
UK  1  (detail)  380380
(75%)
MD1&227.4
(10-53)
37.4
(17-58)
--Positive
IMSGC, 2007
USA  1  (detail)  229229
(79%)
MD1&231.1
(9-51)
39.4
(19-58)
--Positive
IMSGC, 2007
Overlaps with
IMSGC, 2007 (UK-GWAS, CC)
 1  (detail)  453453
(75%)
MD1&226.5
(10-48)
38.2
(19-59)
--Positive
IMSGC, 2007
Overlaps with
IMSGC, 2007 (USA-GWAS, CC)
 1  (detail)  478478
(74%)
MD1&229
(11-51)
39
(17-57)
--Positive
IMSGC, 2009
Australia  1  (detail)  356-MD1&2----Negative
IMSGC, 2009
Belgium  1  (detail)  113-MD1&2----Negative
IMSGC, 2009
UK  1  (detail)  1143-MD1&2----Positive
IMSGC, 2009
USA  1  (detail)  757-MD1&2----Negative
Mero, 2010
UK  6  (detail)  1153-O/M----Positive
Zoledziewska, 2008
Italy (Sardinia)  1  (detail)  410410
(70%)
MD125.1 + 7.4
(6-50)
---Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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