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MSGene - Polymorphism Details
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 Study: Jakkula, 2010
 Gene: STAT3 (APRF; FLJ20882; HIES; MGC16063)
 Protein: signal transducer and activator of transcription 3 (acute-phase response factor)(DNA-binding protein APRF; acute-phase response factor; signal transducer and activator of transcription 3)
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 5 March 2012
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 1

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs744166 Finland-isolate (GWAS) MS
CTR
0.56
0.35
0.44
0.65
21 (0.309)
17 (0.125)
34 (0.500)
62 (0.456)
13 (0.191)
57 (0.419)
rs744166 Finland-isolate (Replication) MS
CTR
0.47
0.41
0.53
0.59
18 (0.217)
60 (0.164)
42 (0.506)
176 (0.482)
23 (0.277)
129 (0.353)
rs744166 Finland-general (Replication) MS
CTR
0.45
0.39
0.55
0.61
125 (0.199)
102 (0.153)
310 (0.494)
318 (0.476)
193 (0.307)
248 (0.371)
rs744166 Norway (Replication) MS
CTR
0.45
0.41
0.55
0.59
122 (0.201)
138 (0.169)
301 (0.496)
395 (0.484)
184 (0.303)
283 (0.347)
rs744166 Denmark (Replication) MS
CTR
0.49
0.43
0.51
0.57
150 (0.239)
197 (0.183)
314 (0.500)
526 (0.490)
164 (0.261)
351 (0.327)
rs744166 Switzerland (GeneMSA-GWAS) MS
CTR
0.41
0.40
0.59
0.60
42 (0.166)
33 (0.159)
123 (0.486)
100 (0.481)
88 (0.348)
75 (0.361)
rs744166 Netherlands (GeneMSA-GWAS) MS
CTR
0.49
0.41
0.51
0.59
55 (0.239)
39 (0.168)
114 (0.496)
113 (0.487)
61 (0.265)
80 (0.345)
rs744166 USA (GeneMSA-GWAS) MS
CTR
0.46
0.39
0.54
0.61
104 (0.214)
66 (0.153)
242 (0.498)
206 (0.478)
140 (0.288)
159 (0.369)
rs744166 UK (IMSGC-GWAS) MS
CTR
0.46
0.44
0.54
0.56
95 (0.210)
571 (0.194)
225 (0.497)
1454 (0.493)
133 (0.294)
925 (0.314)
rs744166 USA (IMSGC-GWAS) MS
CTR
0.43
0.42
0.57
0.58
62 (0.181)
293 (0.175)
167 (0.488)
817 (0.487)
113 (0.330)
569 (0.339)
rs744166 USA (BWH-GWAS) MS
CTR
0.44
0.40
0.56
0.60
169 (0.197)
279 (0.162)
424 (0.493)
828 (0.481)
267 (0.310)
613 (0.356)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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