MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs2234663*1

Polymorphism:

rs2234663*1 (86bpVNTR)

Gene:

IL1RN (DIRA; ICIL-1RA; IL-1ra3; IL1F3; IL1RA; IRAP; MGC10430; MVCD4) View on AlzGene View on PDGene View on SZGene

Protein:

interleukin 1 receptor antagonist(IL1RN (IL1F3); OTTHUMP00000203730; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		other-Allele (frequency)	1-Allele (frequency)	other/other (frequency)	other/1 (frequency)	1/1 (frequency)
Caucasian	15	MS CTR	0.27 0.26	0.73 0.74	296 (0.095) 236 (0.079)	1104 (0.355) 1104 (0.368)	1714 (0.550) 1657 (0.553)
Asian	1	MS CTR	0.05 0.08	0.95 0.92	0 (0.000) 0 (0.000)	9 (0.092) 17 (0.163)	89 (0.908) 87 (0.837)
Total	16	MS CTR	0.27 0.26	0.74 0.74	296 (0.092) 236 (0.076)	1113 (0.347) 1121 (0.361)	1803 (0.561) 1744 (0.562)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism *rs22346631 (86bpVNTR)**

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

IL1RN*Mspsl11100
rs315943
rs315951
rs4251961
rs454078
rs9005

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