Multiple Sclerosis Discovery Forum
  News and Future Directions
  Papers
  Forums
  Professional Resources
  Research Resources
MSGene - Gene overview of all published MS-association studies for IL4R
Back Search Methods Disclaimer Credits
 Gene: IL4R (CD124; IL4RA)   View on SZGene
 Protein: interleukin 4 receptor(OTTHUMP00000122506; interleukin 4 receptor alpha chain; interleukin-4 receptor alpha chain)
 Chromosome: 16   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Aulchenko, 2008
 Netherlands (GWAS) CL  4  (detail)  45
(-)		O/M--195
(-)		-Negative
Ban, 2009
 Belgium CL  1  (detail)  368
(-)		O/M--374
(-)		-Negative
Ban, 2009
 Norway CL  1  (detail)  638
(-)		O/M32
(-)		46.3
(-)		1026
(-)		-Positive
Ban, 2009
 UK (I) CL  1  (detail)  475
(-)		O/M--479
(-)		-Negative
Baranzini, 2008
 USA, Netherlands, Switzerland (GWAS) CL  9  (detail)  978
(67%)		MD1&234
(11-61)		47
(21-69)		883
(66%)		46
(21-69)		Negative
Hackstein, 2001
 Germany CL  6  (detail)  341
(66%)		O/M29.9
(-)		40.3
(-)		305
(46%)		-Positive
IMSGC, 2007
 USA, UK (GWAS) CL,PO  5  (detail)  931
(75%)		MD1&227.8
(10-51)		38.6
(17-59)		2431
(-)		-Negative
Motsinger, 2007
 USA CL  3  (detail)  421
(-)		MD1--96
(-)		-Negative
Nohra, 2010
 Norway CL  3  (detail)  548
(72%)		U-54
(22-90)		554
(54%)		46.6
(34-58)		Negative
Nohra, 2010
 Sweden (I) CL  23  (detail)  1018
(84%)		MD1-53
(22-91)		1215
(63%)		47
(21-76)		Positive
Nohra, 2010
 Sweden (II) CL  5  (detail)  1293
(67%)		U31.5
(11-64)		37
(-)		663
(77%)		-Negative
Quirico-Santos, 2007
 Brazil CL  1  (detail)  74
(-)		MD1--88
(-)		-Negative
Suppiah, 2005
 Ireland CL  1  (detail)  267
(59%)		P33.1 + 11.3
(-)		-179
(-)		-Negative
Suppiah, 2005
 Spain CL  1  (detail)  191
(74%)		P28 + 9.1
(-)		-94
(-)		-Negative
WTCCC, 2007
 UK (GWAS) CL,PO  4  (detail)  994
(72%)		O/M30.3
(10-60)		43.8
(17-79)		1466
(50%)		-Negative
 African Descent
Brassat, 2006
 USA CL  3  (detail)  442
(-)		MD1--293
(-)		-Positive
Quirico-Santos, 2007
 Brazil CL  1  (detail)  55
(-)		MD1--47
(-)		-Positive
 Other/Mixed
Amirzargar, 2007
 Iran CL  1  (detail)  44
(68%)		P--140
(-)		-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Ban, 2009
 Belgium  1  (detail)  113-O/M----Negative
Ban, 2009
 UK (I)  1  (detail)  693-O/M----Negative
Barcellos, 2004
 Overlaps with
Motsinger, 2007 (CC)		  3  (detail)  337337
(-)		U----Negative
Mirel, 2004
 Overlaps with
Motsinger, 2007 (CC)		  3  (detail)  332332
(74%)		U27.1 + 7.9
(-)		35.9
(-)		--Positive
Mirel, 2004
 USA  6  (detail)  332332
(74%)		U27.1 + 7.9
(-)		35.9
(-)		--Positive
Motsinger, 2007
 Overlaps with
Motsinger, 2007 (CC)		  3  (detail)  146146
(-)		MD1----n.a.
Suppiah, 2005
 Belgium  1  (detail)  126126
(60%)		P28.2 + 8
(-)		-126
(-)		-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
Print this page
Email this page
MSDF RSS

Text size
Share & Bookmark
MSGene Recent Updates
MSGene Top Results
Top Results Details
1. HLA-DRB1
2. IL2RA
3. IL7R
4. TAGAP
5. CLEC16A
6. EVI5
7. GWA_16q24.1
8. GWA_5p13.1
9. TTC34
10. AHI1   
[see more]
MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
Copyright © 2024 Biomedical Research Forum LLC Disclaimer Copyright