MSGene

MSGene - Polymorphism Details

Study:

IMSGC, 2010

Gene:

RGS1 (1R20; BL34; IER1; IR20)

Protein:

regulator of G-protein signaling 1 (B-cell activation protein BL34; early response protein 1R20; immediate-early response 1, B-cell specific; regulator of G-protein signalling 1)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Total number of polymorphisms investigated by this study: 1

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs2760524	UK-1 (discovery)	MS CTR	0.16 0.18	0.84 0.82	20 (0.024) 32 (0.031)	218 (0.262) 299 (0.290)	593 (0.714) 699 (0.679)
rs2760524	USA-1 (discovery)	MS CTR	0.15 0.17	0.85 0.83	32 (0.023) 31 (0.029)	357 (0.258) 306 (0.282)	995 (0.719) 748 (0.689)
rs2760524	Finland	MS CTR	0.13 0.15	0.87 0.85	13 (0.016) 23 (0.021)	176 (0.220) 268 (0.248)	610 (0.763) 791 (0.731)
rs2760524	Germany	MS CTR	0.17 0.17	0.83 0.83	27 (0.029) 26 (0.028)	264 (0.282) 258 (0.281)	645 (0.689) 635 (0.691)
rs2760524	Italy	MS CTR	0.13 0.18	0.87 0.82	14 (0.017) 20 (0.031)	190 (0.229) 185 (0.288)	625 (0.754) 437 (0.681)
rs2760524	Sweden	MS CTR	0.15 0.17	0.85 0.83	49 (0.023) 51 (0.029)	542 (0.258) 491 (0.283)	1512 (0.719) 1191 (0.687)
rs2760524	UK-2	MS CTR	0.15 0.17	0.85 0.83	13 (0.022) 22 (0.029)	149 (0.253) 214 (0.286)	428 (0.725) 512 (0.684)
rs2760524	USA-2	MS CTR	0.16 0.18	0.84 0.82	16 (0.026) 17 (0.032)	165 (0.269) 155 (0.290)	432 (0.705) 363 (0.679)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

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