MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs2069762

Polymorphism:

rs2069762 (-384G/T)

Gene:

IL2 (IL-2; TCGF; lymphokine)

View on PDGene View on SZGene

Protein:

interleukin 2 (T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion)

Chromosome:

4 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		G-Allele (frequency)	T-Allele (frequency)	G/G (frequency)	G/T (frequency)	T/T (frequency)
Caucasian	2	MS CTR	0.32 0.29	0.68 0.71	89 (0.094) 91 (0.087)	423 (0.445) 428 (0.407)	438 (0.461) 533 (0.507)
Asian	1	MS CTR	0.12 0.11	0.89 0.89	4 (0.035) 4 (0.034)	18 (0.159) 17 (0.144)	91 (0.805) 97 (0.822)
Other/Mixed	2	MS CTR	0.38 0.43	0.62 0.57	25 (0.044) 96 (0.122)	387 (0.678) 476 (0.607)	159 (0.278) 212 (0.270)
Total	5	MS CTR	0.33 0.33	0.67 0.67	118 (0.072) 191 (0.098)	828 (0.507) 921 (0.471)	688 (0.421) 842 (0.431)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs2069762 (-384G/T)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

IL2_166G/T
rs11938795
rs17388568
rs2069763 (114T/G)
rs3136534
rs34662806 (2bpSTR-3'UTR)

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