MSGene

MSGene - Gene overview of all published MS-association studies for IL2

Gene:

IL2 (IL-2; TCGF; lymphokine)

View on PDGene View on SZGene

Protein:

interleukin 2 (T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion)

Chromosome:

4 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Baranzini, 2008	USA, Netherlands, Switzerland (GWAS)	CL	1 (detail)	978 (67%)	MD1&2	34 (11-61)	47 (21-69)	883 (66%)	46 (21-69)	Negative
Cavanillas, 2010	Spain (I)	CL	2 (detail)	430 (65%)	P	-	29 (16-79)	550 (-)	-	Negative
Epplen, 1995	Overlaps with Epplen, 1997	CL	1 (detail)	350 (-)	U	-	-	300 (-)	-	n.a.
Epplen, 1997	Germany	CL	1 (detail)	358 (66%)	P	29 (11-50)	-	395 (29%)	38 (23-60)	Negative
Fedetz, 2009	Spain	CL	2 (detail)	805 (68%)	P	28.6 + 10.5 (-)	36 (-)	952 (61%)	38 (-)	Negative
He, 1998	Sweden	CL	1 (detail)	147 (-)	P	-	-	95 (-)	-	Negative
IMSGC, 2007	USA, UK (GWAS)	CL,PO	1 (detail)	931 (75%)	MD1&2	27.8 (10-51)	38.6 (17-59)	2431 (-)	-	Negative
Matesanz, 2001	Spain	CL	2 (detail)	173 (-)	U	-	-	153 (-)	-	Positive
McDonnell, 2000	UK (Northern Ireland)	CL	1 (detail)	287 (-)	P	-	-	216 (-)	-	Negative
Asian
Kikuchi, 2002	Japan	CL	2 (detail)	113 (73%)	MD1	26.5 + 9 (-)	35.2 + 10.8 (-)	118 (78%)	33.1 + 9.4 (20-58)	Negative
Other/Mixed
Ali Shokrgozar, 2009	Iran	CL	2 (detail)	211 (74%)	MD1	27 (-)	31.2 + 7 (-)	359 (-)	-	Negative
Amirzargar, 2007	Overlaps with Ali Shokrgozar, 2009	CL	2 (detail)	44 (68%)	P	-	-	140 (-)	-	n.a.
Shahbazi, 2010	Iran	CL	1 (detail)	360 (83%)	MD1	26 + 6 (10-46)	31 + 9 (19-57)	426 (-)	39 + 7 (35-64)	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Feakes, 2000	UK	1 (detail)	502	-	U	-	-	-	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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