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MSGene - Gene overview of all published MS-association studies for CCR5
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 Gene: CCR5  (CC-CKR-5; CCCKR5; CD195; CKR-5; CKR5; CMKBR5; FLJ78003; IDDM22)  Entrez Gene    View on AlzGene   View on PDGene   View on SZGene
 Protein: chemokine (C-C motif) receptor 5  (C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; OTTHUMP00000209784; chemokine receptor CCR5; chemr13)  ProteinLink
 Chromosome: 3   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 23 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Barcellos, 2000
USA (II) CL  1  (detail)  299
(-)
U--147
(-)
-Negative
Barcellos, 2000
USA (I) CL  1  (detail)  125
(-)
O/M----Negative
Bennetts, 1997
Australia CL  1  (detail)  120
(-)
P--168
(-)
-Negative
D’Angelo, 2011
Italy (Sicily) CL  1  (detail)  180
(73%)
P29.4 + 7.8
(-)
44.8 + 8
(-)
213
(71%)
44 + 11.4
(-)
Positive
Favorova, 2002
Russia CL  1  (detail)  219
(57%)
P23 + 9
(-)
33 + 12
(-)
354
(62%)
28 + 10
(-)
Positive
Favorova, 2006
Overlaps with
Favorova, 2002
CL  1  (detail)  268
(66%)
MD123 + 9
(-)
33 + 12
(-)
362
(44%)
30 + 11
(-)
n.a.
Gade-Andavolu, 2004
USA CL  1  (detail)  132
(64%)
O/M34.6
(18-57)
57.2
(30-86)
163
(52%)
34.3
(18-49)
Positive
Luomala, 2003
Finland CL  1  (detail)  116
(58%)
P-46 + 10
(24-78)
109
(-)
46 + 10
(23-78)
Negative
Motsinger, 2007
Overlaps with
Barcellos, 2000
CL  1  (detail)  421
(-)
MD1--96
(-)
-Negative
Otaegui, 2007
Spain (Other origin) CL  1  (detail)  102
(-)
MD1--226
(-)
-Positive
Otaegui, 2007
Spain (Basque) CL  1  (detail)  62
(-)
MD1--147
(-)
-Positive
Pulkkinen, 2004
Overlaps with
Luomala, 2003
CL  1  (detail)  89
(-)
U32.2
(-)
46 + 10.2
(-)
119
(-)
45.7 + 10.2
(-)
n.a.
Ristic, 2006
Croatia, Slovenia CL  1  (detail)  325
(71%)
P29.4 + 8.9
(-)
43.1
(-)
356
(-)
-Negative
Schreiber, 2002
Overlaps with
Sellebjerg, 2007
PO  1  (detail)  71
(-)
U--151
(-)
-n.a.
Sellebjerg, 2000
Denmark CL  1  (detail)  148
(73%)
P-33.2
(-)
151
(-)
-Negative
Sellebjerg, 2007
Denmark CL  2  (detail)  109
(75%)
U-42
(-)
105
(70%)
38
(-)
Negative
Silversides, 2004
UK (Northern Ireland) CL,PO  1  (detail)  439
(-)
U--230
(-)
-Trend
van Veen, 2007
Netherlands CL  2  (detail)  729
(-)
P--177
(54%)
43
(-)
Positive
Zhang, 2005
Sweden CL  2  (detail)  672
(72%)
P31.5
(-)
45.6
(15-80)
672
(49%)
54.5
(17-91)
Negative
 African Descent
Brassat, 2006
USA CL  2  (detail)  442
(-)
MD1--293
(-)
-Negative
 Other/Mixed
Kaimen-Maciel, 2007
Brazil CL  1  (detail)  124
(69%)
MD1&2-44.2 + 11.9
(18-79)
127
(44%)
30 + 10.1
(18-60)
Positive
Shahbazi, 2009
Iran CL  1  (detail)  254
(83%)
MD126 + 7
(-)
32.2 + 8.6
(-)
380
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Barcellos, 2000
Overlaps with
Barcellos, 2000 (CC)
 1  (detail)  125-O/M----n.a.
Barcellos, 2004
USA  1  (detail)  337337
(-)
U----Negative
Chataway, 1999
UK  2  (detail)  185-U----Negative
Motsinger, 2007
Overlaps with
Barcellos, 2000 (CC)
 1  (detail)  146146
(-)
MD1----n.a.
Motsinger, 2007
Overlaps with
Barcellos, 2000 (CC)
 1  (detail)  275-MD1----Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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