MSGene

MSGene - Gene overview of all published MS-association studies for CCR5

Gene:

CCR5 (CC-CKR-5; CCCKR5; CD195; CKR-5; CKR5; CMKBR5; FLJ78003; IDDM22)

View on AlzGene View on PDGene View on SZGene

Protein:

chemokine (C-C motif) receptor 5 (C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; OTTHUMP00000209784; chemokine receptor CCR5; chemr13)

Chromosome:

3 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 November 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Barcellos, 2000	USA (II)	CL	1 (detail)	299 (-)	U	-	-	147 (-)	-	Negative
Barcellos, 2000	USA (I)	CL	1 (detail)	125 (-)	O/M	-	-	-	-	Negative
Bennetts, 1997	Australia	CL	1 (detail)	120 (-)	P	-	-	168 (-)	-	Negative
D’Angelo, 2011	Italy (Sicily)	CL	1 (detail)	180 (73%)	P	29.4 + 7.8 (-)	44.8 + 8 (-)	213 (71%)	44 + 11.4 (-)	Positive
Favorova, 2002	Russia	CL	1 (detail)	219 (57%)	P	23 + 9 (-)	33 + 12 (-)	354 (62%)	28 + 10 (-)	Positive
Favorova, 2006	Overlaps with Favorova, 2002	CL	1 (detail)	268 (66%)	MD1	23 + 9 (-)	33 + 12 (-)	362 (44%)	30 + 11 (-)	n.a.
Gade-Andavolu, 2004	USA	CL	1 (detail)	132 (64%)	O/M	34.6 (18-57)	57.2 (30-86)	163 (52%)	34.3 (18-49)	Positive
Luomala, 2003	Finland	CL	1 (detail)	116 (58%)	P	-	46 + 10 (24-78)	109 (-)	46 + 10 (23-78)	Negative
Motsinger, 2007	Overlaps with Barcellos, 2000	CL	1 (detail)	421 (-)	MD1	-	-	96 (-)	-	Negative
Otaegui, 2007	Spain (Other origin)	CL	1 (detail)	102 (-)	MD1	-	-	226 (-)	-	Positive
Otaegui, 2007	Spain (Basque)	CL	1 (detail)	62 (-)	MD1	-	-	147 (-)	-	Positive
Pulkkinen, 2004	Overlaps with Luomala, 2003	CL	1 (detail)	89 (-)	U	32.2 (-)	46 + 10.2 (-)	119 (-)	45.7 + 10.2 (-)	n.a.
Ristic, 2006	Croatia, Slovenia	CL	1 (detail)	325 (71%)	P	29.4 + 8.9 (-)	43.1 (-)	356 (-)	-	Negative
Schreiber, 2002	Overlaps with Sellebjerg, 2007	PO	1 (detail)	71 (-)	U	-	-	151 (-)	-	n.a.
Sellebjerg, 2000	Denmark	CL	1 (detail)	148 (73%)	P	-	33.2 (-)	151 (-)	-	Negative
Sellebjerg, 2007	Denmark	CL	2 (detail)	109 (75%)	U	-	42 (-)	105 (70%)	38 (-)	Negative
Silversides, 2004	UK (Northern Ireland)	CL,PO	1 (detail)	439 (-)	U	-	-	230 (-)	-	Trend
van Veen, 2007	Netherlands	CL	2 (detail)	729 (-)	P	-	-	177 (54%)	43 (-)	Positive
Zhang, 2005	Sweden	CL	2 (detail)	672 (72%)	P	31.5 (-)	45.6 (15-80)	672 (49%)	54.5 (17-91)	Negative
African Descent
Brassat, 2006	USA	CL	2 (detail)	442 (-)	MD1	-	-	293 (-)	-	Negative
Other/Mixed
Kaimen-Maciel, 2007	Brazil	CL	1 (detail)	124 (69%)	MD1&2	-	44.2 + 11.9 (18-79)	127 (44%)	30 + 10.1 (18-60)	Positive
Shahbazi, 2009	Iran	CL	1 (detail)	254 (83%)	MD1	26 + 7 (-)	32.2 + 8.6 (-)	380 (-)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Barcellos, 2000	Overlaps with Barcellos, 2000 (CC)	1 (detail)	125	-	O/M	-	-	-	-	n.a.
Barcellos, 2004	USA	1 (detail)	337	337 (-)	U	-	-	-	-	Negative
Chataway, 1999	UK	2 (detail)	185	-	U	-	-	-	-	Negative
Motsinger, 2007	Overlaps with Barcellos, 2000 (CC)	1 (detail)	146	146 (-)	MD1	-	-	-	-	n.a.
Motsinger, 2007	Overlaps with Barcellos, 2000 (CC)	1 (detail)	275	-	MD1	-	-	-	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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