MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs333

Polymorphism:

rs333 (delta32)

Gene:

CCR5 (CC-CKR-5; CCCKR5; CD195; CKR-5; CKR5; CMKBR5; FLJ78003; IDDM22)

View on AlzGene View on PDGene View on SZGene

Protein:

chemokine (C-C motif) receptor 5 (C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; OTTHUMP00000209784; chemokine receptor CCR5; chemr13)

Chromosome:

3 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		Del-Allele (frequency)	Ins-Allele (frequency)	Del/Del (frequency)	Del/Ins (frequency)	Ins/Ins (frequency)
Caucasian	11	MS CTR	0.10 0.10	0.90 0.90	35 (0.014) 22 (0.011)	411 (0.168) 333 (0.171)	1994 (0.817) 1591 (0.818)
Other/Mixed	2	MS CTR	0.14 0.08	0.87 0.92	37 (0.098) 10 (0.020)	28 (0.074) 59 (0.116)	313 (0.828) 438 (0.864)
Total	13	MS CTR	0.10 0.09	0.90 0.91	72 (0.026) 32 (0.013)	439 (0.156) 392 (0.160)	2307 (0.819) 2029 (0.827)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs333 (delta32)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

CCR5_-2454A/G
CCR5_prom
D3S4579
rs1799987 (-2459A/G)
rs1800024
rs1800874

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