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MSGene - Gene overview of all published MS-association studies for ICAM1
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 Gene: ICAM1  (BB2; CD54; P3.58)  Entrez Gene    View on ALSGene   View on AlzGene   View on PDGene   View on SZGene
 Protein: intercellular adhesion molecule 1  (cell surface glycoprotein P3.58; human rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor)  ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  2  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Killestein, 2000
Overlaps with
Baranzini, 2008 (Netherlands)
CL  2  (detail)  145
(-)
U--106
(-)
-n.a.
Luomala, 1999
Overlaps with
Luomala, 2000
CL  1  (detail)  91
(-)
U--113
(-)
-n.a.
Luomala, 2000
Finland CL  1  (detail)  104
(57%)
U--111
(61%)
-Positive
Motsinger, 2007
USA CL  2  (detail)  421
(-)
MD1--96
(-)
-Negative
Mycko, 1998
Poland CL  2  (detail)  79
(-)
P--68
(-)
-Positive
Nejentsev, 2003
Finland CL,PO  1  (detail)  277
(-)
P--573
(-)
-Positive
Nejentsev, 2003
Spain CL  1  (detail)  140
(-)
P--113
(-)
-Positive
WTCCC, 2007
UK (GWAS) CL,PO  2  (detail)  994
(72%)
O/M30.3
(10-60)
43.8
(17-79)
1466
(50%)
-Negative
Zhang, 2005
Sweden CL  2  (detail)  672
(72%)
P31.5
(-)
45.6
(15-80)
672
(49%)
54.5
(17-91)
Negative
 African Descent
Brassat, 2006
USA CL  2  (detail)  442
(-)
MD1--293
(-)
-Negative
 Other/Mixed
Mousavi, 2007
Iran CL  2  (detail)  157
(76%)
MD1--156
(69%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Barcellos, 2004
Overlaps with
Motsinger, 2007 (CC)
 2  (detail)  337337
(-)
U----Negative
Cournu-Rebeix, 2003
France  3  (detail)  439439
(68%)
O/M26 + 7
(-)
35
(-)
--Positive
Marrosu, 2000
Italy (Sardinia)  2  (detail)  157-P----Negative
Motsinger, 2007
Overlaps with
Motsinger, 2007 (CC)
 2  (detail)  146146
(-)
MD1----n.a.
Nejentsev, 2003
Finland, Spain  1  (detail)  276276
(-)
P----Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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