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MSGene - Gene overview of all published MS-association studies for TNFRSF1B
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 Gene: TNFRSF1B  (CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR)  Entrez Gene    View on ALSGene   View on AlzGene   View on SZGene
 Protein: tumor necrosis factor receptor superfamily, member 1B  (p75 TNF receptor; soluble TNFR1B variant 1; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; tumor necrosis factor receptor 2)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  3  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Ehling, 2004
Austria CL  5  (detail)  321
(73%)
P28.1
(22-33)
40.9
(33-47)
174
(39%)
26 + 9.4
(-)
Positive
WTCCC, 2007
UK (GWAS) CL,PO  2  (detail)  994
(72%)
O/M30.3
(10-60)
43.8
(17-79)
1466
(50%)
-Negative
Zhang, 2005
Sweden CL  2  (detail)  672
(72%)
P31.5
(-)
45.6
(15-80)
672
(49%)
54.5
(17-91)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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