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MSGene - Gene overview of all published MS-association studies for VDR
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 Gene: VDR (NR1I1)   View on ALSGene   View on AlzGene   View on PDGene   View on SZGene
 Protein: vitamin D (1,25- dihydroxyvitamin D3) receptor(vitamin D (1,25-dihydroxyvitamin D3) receptor)
 Chromosome: 12   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Agliardi, 2011
 Italy (I+II) CL  1  (detail)  1153
(67%)		MD127.8 + 9.2
(-)		-807
(67%)		29.4 + 6.5
(-)		Positive
Agliardi, 2011
 Italy (I) CL  2  (detail)  512
(-)		MD1--249
(-)		-Positive
Baranzini, 2008
 USA, Netherlands, Switzerland (GWAS) CL  3  (detail)  978
(67%)		MD1&234
(11-61)		47
(21-69)		883
(66%)		46
(21-69)		Negative
Cox, 2011
 UK, Australia CL  2  (detail)  727
(-)		MD2--604
(-)		-Positive
Dickinson, 2009
 Australia PO  3  (detail)  136
(68%)		P31 + 9.1
(-)		43.5 + 9.3
(-)		235
(78%)		43.6 + 9.2
(-)		Positive
IMSGC, 2007
 USA, UK (GWAS) CL,PO  3  (detail)  931
(75%)		MD1&227.8
(10-51)		38.6
(17-59)		2431
(-)		-Negative
Motsinger, 2007
 USA CL  2  (detail)  421
(-)		MD1--96
(-)		-Negative
Partridge, 2004
 UK CL  2  (detail)  419
(75%)		P31 + 9.8
(-)		43.8 + 11.2
(-)		422
(74%)		50.1
(-)		Positive
Simon, 2009
 USA (NHS-Women) CL  5  (detail)  214
(100%)		O/M--428
(100%)		-Negative
Sioka, 2011
 Greece CL  2  (detail)  69
(-)		MD1-39 + 10.5
(-)		81
(-)		38.7 + 10.7
(-)		Negative
Smolders, 2009
 Netherlands CL  3  (detail)  212
(71%)		MD134
(-)		46.7 + 11.9
(-)		289
(50%)		34.9 + 14.3
(-)		Negative
Tajouri, 2005
 Australia CL  3  (detail)  104
(75%)		U--104
(-)		-Positive
 African Descent
Brassat, 2006
 USA CL  2  (detail)  442
(-)		MD1--293
(-)		-Negative
 Asian
Fukazawa, 1999
 Japan CL  1  (detail)  77
(73%)		P25.6 + 8.9
(15-48)		36.2 + 11.2
(16-58)		95
(65%)		34.4 + 10.2
(20-61)		Positive
Niino, 2000
 Overlaps with
Fukazawa, 1999		 CL  1  (detail)  77
(73%)		P25.6 + 8.9
(15-48)		36.2 + 11.2
(16-58)		95
(65%)		34.4 + 10.2
(20-61)		n.a.
Niino, 2000
 Japan CL  1  (detail)  77
(73%)		P25.6 + 8.9
(15-48)		36.2 + 11.2
(16-58)		95
(65%)		34.4 + 10.2
(20-61)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Barcellos, 2004
 Overlaps with
Motsinger, 2007 (CC)		  2  (detail)  337337
(-)		U----Negative
de Abreu, 2009
 France  3  (detail)  583-P----Negative
Motsinger, 2007
 Overlaps with
Motsinger, 2007 (CC)		  2  (detail)  275-MD1----n.a.
Orton, 2008
 Canada  3  (detail)  99115
(-)		U--83
(-)		-Negative
Steckley, 2000
 Canada  2  (detail)  187-U----Negative
Yeo, 2004
 UK  4  (detail)  380-U----Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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