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MSGene - Gene overview of all published MS-association studies for IL10
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 Gene: IL10  (CSIF; IL-10; IL10A; MGC126450; MGC126451; TGIF)  Entrez Gene    View on AlzGene   View on PDGene   View on SZGene
 Protein: interleukin 10  (cytokine synthesis inhibitory factor)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Almeras, 2002
France CL  2  (detail)  153
(69%)
P33.1
(-)
39.5 + 10.8
(16-69)
184
(58%)
29.9 + 7
(18-62)
Positive
Azarpira, 2010
Iran CL  3  (detail)  110
(71%)
P-32.2
(-)
100
(51%)
33.4
(-)
Negative
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  1  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
De Jong, 2002
Overlaps with
Baranzini, 2008 (Netherlands)
CL  5  (detail)  251
(59%)
P33.5 + 9.6
(-)
47.5 + 11.3
(-)
321
(47%)
39 + 17
(-)
Positive
Doncel, 2002
Spain CL  5  (detail)  300
(67%)
P--357
(-)
-Trend
Forte, 2006
Italy CL  1  (detail)  91
(-)
U--220
(-)
-Negative
He, 1998
Sweden CL  1  (detail)  147
(-)
P--95
(-)
-Negative
Luomala, 2003
Finland CL  1  (detail)  116
(58%)
P-46 + 10
(24-78)
400
(-)
-Positive
Maeurer, 2000
Germany CL  1  (detail)  181
(-)
U--85
(-)
-Negative
McDonnell, 2000
UK (Northern Ireland) CL  1  (detail)  287
(-)
P--216
(-)
-Negative
Mihailova, 2005
Bulgaria CL  3  (detail)  55
(56%)
P27.3 + 7.1
(-)
32.3 + 9.5
(-)
86
(-)
-Positive
Mirowska-Guzel, 2011
Poland CL  1  (detail)  230
(73%)
MD1&229 + 9.9
(-)
38.1 + 10.9
(-)
195
(67%)
40 + 10.1
(-)
Negative
Motsinger, 2007
USA CL  1  (detail)  421
(-)
MD1--96
(-)
-Negative
Myhr, 2002
Norway PO  3  (detail)  168
(65%)
P32.5 + 0.6
(-)
46.9
(-)
87
(-)
-Trend
Pickard, 1999
UK CL  4  (detail)  185
(74%)
P31.4 + 9
(-)
41.7 + 10.6
(-)
211
(-)
-Negative
 African Descent
Brassat, 2006
USA CL  1  (detail)  442
(-)
MD1--293
(-)
-Negative
 Other/Mixed
Amirzargar, 2007
Iran CL  3  (detail)  44
(68%)
P--140
(-)
-Negative
Izad, 2010
Overlaps with
Amirzargar, 2007
CL  3  (detail)  98
(66%)
P27.3 + 9.7
(-)
37.7 + 10.4
(-)
97
(42%)
25 + 20
(-)
n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Barcellos, 2004
Overlaps with
Motsinger, 2007 (CC)
 1  (detail)  337337
(-)
U----Negative
Doncel, 2002
Overlaps with
Doncel, 2002 (CC)
 5  (detail)  63-P----Negative
Motsinger, 2007
Overlaps with
Motsinger, 2007 (CC)
 1  (detail)  275-MD1----n.a.
Motsinger, 2007
Overlaps with
Motsinger, 2007 (CC)
 1  (detail)  146146
(-)
MD1----n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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