MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs1800872

Polymorphism:

rs1800872 (-592A/C)

Gene:

IL10 (CSIF; IL-10; IL10A; MGC126450; MGC126451; TGIF)

View on AlzGene View on PDGene View on SZGene

Protein:

interleukin 10 (cytokine synthesis inhibitory factor)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		A-Allele (frequency)	C-Allele (frequency)	A/A (frequency)	A/C (frequency)	C/C (frequency)
Caucasian	4	MS CTR	0.23 0.26	0.78 0.74	34 (0.065) 40 (0.083)	167 (0.320) 176 (0.364)	321 (0.615) 268 (0.554)
Other/Mixed	1	MS CTR	0.28 0.29	0.72 0.71	2 (0.045) 12 (0.086)	21 (0.477) 57 (0.407)	21 (0.477) 71 (0.507)
Total	5	MS CTR	0.23 0.27	0.77 0.73	36 (0.064) 52 (0.083)	188 (0.332) 233 (0.373)	342 (0.604) 339 (0.543)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs1800872 (-592A/C)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

IL10_2bpSTR-G
IL10_2bpSTR-R
rs1800890 (-3575T/A)
rs6693899 (-2763C/A)
rs6703630 (-2849G/A)

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