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MSGene - Gene overview of all published MS-association studies for IL2
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 Gene: IL2  (IL-2; TCGF; lymphokine)  Entrez Gene    View on PDGene   View on SZGene
 Protein: interleukin 2  (T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion)  ProteinLink
 Chromosome: 4   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  1  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Cavanillas, 2010
Spain (I) CL  2  (detail)  430
(65%)
P-29
(16-79)
550
(-)
-Negative
Epplen, 1995
Overlaps with
Epplen, 1997
CL  1  (detail)  350
(-)
U--300
(-)
-n.a.
Epplen, 1997
Germany CL  1  (detail)  358
(66%)
P29
(11-50)
-395
(29%)
38
(23-60)
Negative
Fedetz, 2009
Spain CL  2  (detail)  805
(68%)
P28.6 + 10.5
(-)
36
(-)
952
(61%)
38
(-)
Negative
He, 1998
Sweden CL  1  (detail)  147
(-)
P--95
(-)
-Negative
IMSGC, 2007
USA, UK (GWAS) CL,PO  1  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Negative
Matesanz, 2001
Spain CL  2  (detail)  173
(-)
U--153
(-)
-Positive
McDonnell, 2000
UK (Northern Ireland) CL  1  (detail)  287
(-)
P--216
(-)
-Negative
 Asian
Kikuchi, 2002
Japan CL  2  (detail)  113
(73%)
MD126.5 + 9
(-)
35.2 + 10.8
(-)
118
(78%)
33.1 + 9.4
(20-58)
Negative
 Other/Mixed
Ali Shokrgozar, 2009
Iran CL  2  (detail)  211
(74%)
MD127
(-)
31.2 + 7
(-)
359
(-)
-Negative
Amirzargar, 2007
Overlaps with
Ali Shokrgozar, 2009
CL  2  (detail)  44
(68%)
P--140
(-)
-n.a.
Shahbazi, 2010
Iran CL  1  (detail)  360
(83%)
MD126 + 6
(10-46)
31 + 9
(19-57)
426
(-)
39 + 7
(35-64)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Feakes, 2000
UK  1  (detail)  502-U----Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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