MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs3748816

Polymorphism:

rs3748816

Gene:

MMEL1 (RP3-395M20.11; MGC119454; MGC119455; MGC119456; MMEL2; NEP2; NEPII; NL1; NL2; SEP)

Protein:

membrane metallo-endopeptidase-like 1 (NEP2(m); membrane metallo-endopeptidase-like 2; neprilysin II; neprilysin-2; soluble secreted endopeptidase; zinc metallopeptidase)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		C-Allele (frequency)	T-Allele (frequency)	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian	5	MS CTR	0.30 0.33	0.70 0.67	317 (0.093) 288 (0.112)	1429 (0.420) 1141 (0.442)	1659 (0.487) 1151 (0.446)
Other/Mixed	1	MS CTR	0.56 0.60	0.44 0.40	62 (0.315) 70 (0.355)	97 (0.492) 95 (0.482)	38 (0.193) 32 (0.162)
Total	6	MS CTR	0.32 0.35	0.68 0.65	379 (0.105) 358 (0.129)	1526 (0.424) 1236 (0.445)	1697 (0.471) 1183 (0.426)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs3748816

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs6684865

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