MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs361525

Polymorphism:

rs361525 (-238A/G)

Gene:

TNF (DADB-70P7.1; DIF; TNF-alpha; TNFA; TNFSF2)

View on ALSGene View on AlzGene View on PDGene View on SZGene

Protein:

tumor necrosis factor (TNF superfamily, member 2) (APC1 protein; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; cachectin; tumor necrosis factor alpha)

Chromosome:

6 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		A-Allele (frequency)	G-Allele (frequency)	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian	9	MS CTR	0.06 0.07	0.94 0.94	7 (0.005) 12 (0.007)	135 (0.102) 198 (0.115)	1177 (0.892) 1509 (0.878)
Other/Mixed	2	MS CTR	0.06 0.18	0.94 0.82	0 (0.000) 1 (0.006)	14 (0.115) 61 (0.347)	108 (0.885) 114 (0.648)
Total	11	MS CTR	0.06 0.08	0.94 0.93	7 (0.005) 13 (0.007)	149 (0.103) 259 (0.137)	1285 (0.892) 1623 (0.856)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs361525 (-238A/G)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

D6S2810 (MIB)
TNF_68indel-C

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