MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs12720460

Polymorphism:

rs12720460 (4bp-indel)

Gene:

NOS2 (HEP-NOS; INOS; NOS; NOS2A) View on AlzGene View on PDGene

Protein:

nitric oxide synthase 2, inducible(NOS, type II; nitric oxide synthase 2A; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase, macrophage)

Chromosome:

17 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 21 June 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		TAAA-Allele (frequency)	del-Allele (frequency)	TAAA/TAAA (frequency)	TAAA/del (frequency)	del/del (frequency)
Caucasian	4	MS CTR	0.12 0.13	0.88 0.87	9 (0.017) 17 (0.027)	114 (0.209) 132 (0.208)	422 (0.774) 485 (0.765)
Total	4	MS CTR	0.12 0.13	0.88 0.87	9 (0.017) 17 (0.027)	114 (0.209) 132 (0.208)	422 (0.774) 485 (0.765)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs12720460 (4bp-indel)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

D17S582
NOS2_-1026G/T
NOS2_-1659C/T
NOS2_-2447C/G
NOS2_-277A/G
NOS2_5bpSTR-prom (CCTTTn)
NOS2_5bpSTR-prom (CCTTTn)
NOS2_S569L
rs1060826
rs1137933 (D346D)
rs12720460 (4bp-indel)
rs2248814
rs2297518
rs2301369
rs2779248
rs3729508
rs3730013
rs3794764
rs4796052
rs8078340
rs8081248

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