MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs1801133

Polymorphism:

rs1801133 (677C/T)

Gene:

MTHFR

View on ALSGene View on AlzGene View on PDGene View on SZGene

Protein:

5,10-methylenetetrahydrofolate reductase (NADPH) (5,10-methylenetetrahydrofolate reductase; OTTHUMP00000002367; methylenetetrahydrofolate reductase intermediate form)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		T-Allele (frequency)	C-Allele (frequency)	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian	2	MS CTR	0.29 0.30	0.71 0.70	26 (0.109) 22 (0.092)	85 (0.356) 98 (0.412)	128 (0.536) 118 (0.496)
Other/Mixed	1	MS CTR	0.27 0.23	0.73 0.77	15 (0.077) 10 (0.043)	74 (0.381) 85 (0.370)	105 (0.541) 135 (0.587)
Total	3	MS CTR	0.28 0.26	0.72 0.74	41 (0.095) 32 (0.068)	159 (0.367) 183 (0.391)	233 (0.538) 253 (0.541)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs1801133 (677C/T)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs1801131 (1298A/C)

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