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MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs662

Polymorphism:

rs662 (Q192R)

Gene:

PON1 (ESA; MVCD5; PON) View on ALSGene View on AlzGene View on PDGene View on SZGene

Protein:

paraoxonase 1(arylesterase B-type; esterase A; paraoxonase B-type; serum aryldiakylphosphatase)

Chromosome:

7 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		G-Allele (frequency)	A-Allele (frequency)	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian	2	MS CTR	0.19 0.17	0.81 0.84	23 (0.053) 23 (0.053)	117 (0.268) 97 (0.224)	297 (0.680) 313 (0.723)
Other/Mixed	1	MS CTR	0.29 0.33	0.71 0.67	9 (0.143) 10 (0.159)	19 (0.302) 22 (0.349)	35 (0.556) 31 (0.492)
Total	3	MS CTR	0.20 0.19	0.80 0.81	32 (0.064) 33 (0.067)	136 (0.272) 119 (0.240)	332 (0.664) 344 (0.694)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs662 (Q192R)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs854560 (L55M)

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