MSGene

MSGene - Gene overview of all published MS-association studies for SH2D2A

Gene:

SH2D2A (F2771; SCAP; TSAD; VRAP)

Protein:

SH2 domain protein 2A (SH2 domain-containing adapter protein; T cell specific adapter protein TSAd; T lymphocyte specific adaptor protein; VEGF receptor-associated protein)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 31 January 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Dai, 2001	Overlaps with Lorentzen, 2008	CL	1 (detail)	313 (-)	P	-	-	277 (-)	-	n.a.
Lorentzen, 2008	Denmark	CL	2 (detail)	620 (-)	O/M	-	-	553 (-)	-	Positive
Lorentzen, 2008	Sweden	CL	2 (detail)	644 (-)	O/M	-	-	649 (-)	-	Positive
Lorentzen, 2008	Finland	CL	2 (detail)	240 (-)	O/M	-	-	240 (-)	-	Positive
Lorentzen, 2008	Norway	CL	6 (detail)	624 (58%)	O/M	31.1 (10-62)	-	562 (58%)	-	Positive
WTCCC, 2007	UK (GWAS)	CL,PO	1 (detail)	994 (72%)	O/M	30.3 (10-60)	43.8 (17-79)	1466 (50%)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Dai, 2001	Denmark	1 (detail)	58	-	P	-	-	-	-	Positive
Dai, 2001	Norway	1 (detail)	40	-	P	-	-	-	-	Positive
Dai, 2001	Finland	1 (detail)	14	-	P	-	-	-	-	Positive
Dai, 2001	Sweden	1 (detail)	38	-	P	-	-	-	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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