MSGene

MSGene - Gene overview of all published MS-association studies for ACE

Gene:

ACE (ACE1; CD143; DCP; DCP1; MGC26566; MVCD3) View on ALSGene View on AlzGene View on PDGene View on SZGene

Protein:

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1(CD143 antigen; angiotensin I converting enzyme 1; angiotensin converting enzyme, somatic isoform; carboxycathepsin; dipeptidyl carboxypeptidase 1; kininase II; peptidase P; testicular ECA)

Chromosome:

17 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Baranzini, 2008	USA, Netherlands, Switzerland (GWAS)	CL	2 (detail)	978 (67%)	MD1&2	34 (11-61)	47 (21-69)	883 (66%)	46 (21-69)	Negative
Hladikova, 2011	Czech Republic	CL	1 (detail)	195 (75%)	MD2	-	37.6 + 9.3 (-)	126 (65%)	-	Negative
Klupka-Saric, 2011	Bosnia, Herzegovina	CL	1 (detail)	170 (71%)	MD2	30.7 + 8.3 (-)	39.4 + 9.3 (-)	170 (-)	-	Negative
Lovrecic, 2006	Slovenia, Croatia	CL	1 (detail)	313 (71%)	P	29.2 + 8.8 (-)	43.1 + 12.1 (-)	376 (-)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Saarela, 2006	Finland (I)	2 (detail)	63	97 (-)	P	-	-	230 (-)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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