MSGene

MSGene - Polymorphism Details

Study:

Fenoglio, 2010

Gene:

GRN (GEP; GP88; PCDGF; PEPI; PGRN)

Protein:

granulin (PC cell-derived growth factor; acrogranin; granulin-epithelin; granulins; proepithelin; progranulin)

Chromosome:

17 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 21 July 2010

Total number of polymorphisms investigated by this study: 5

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs2879096	Italy-I	MS CTR	0.27 0.24	0.73 0.76	33 (0.093) 18 (0.052)	123 (0.347) 127 (0.370)	198 (0.559) 198 (0.577)
rs2879096	Italy-II (PP only)	MS CTR	0.27 0.22	0.73 0.78	15 (0.067) 10 (0.043)	89 (0.397) 83 (0.356)	120 (0.536) 140 (0.601)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs3785817	Italy-II (PP only)	MS CTR	0.27 0.26	0.73 0.74	16 (0.071) 15 (0.064)	90 (0.402) 89 (0.382)	118 (0.527) 129 (0.554)
rs3785817	Italy-I	MS CTR	0.27 0.26	0.73 0.74	34 (0.096) 22 (0.064)	125 (0.353) 132 (0.385)	195 (0.551) 189 (0.551)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	G-Allele	C/C (frequency)	C/G (frequency)	G/G (frequency)
Caucasian
rs4792938	Italy-I	MS CTR	0.35 0.34	0.65 0.66	54 (0.153) 45 (0.131)	142 (0.401) 140 (0.408)	158 (0.446) 158 (0.461)
rs4792938	Italy-II (PP only)	MS CTR	0.36 0.33	0.64 0.67	30 (0.134) 30 (0.129)	100 (0.446) 93 (0.399)	94 (0.420) 110 (0.472)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs9897526	Italy-II (PP only)	MS CTR	0.14 0.15	0.86 0.85	0 (0.000) 8 (0.034)	62 (0.277) 53 (0.227)	162 (0.723) 172 (0.738)
rs9897526	Italy-I	MS CTR	0.13 0.16	0.87 0.84	7 (0.020) 11 (0.032)	76 (0.215) 89 (0.259)	271 (0.766) 243 (0.708)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs5848	Italy-I	MS CTR	0.31 0.33	0.69 0.67	32 (0.090) 36 (0.105)	155 (0.438) 153 (0.446)	167 (0.472) 154 (0.449)
rs5848	Italy-II (PP only)	MS CTR	0.35 0.32	0.65 0.68	27 (0.121) 26 (0.112)	102 (0.455) 96 (0.412)	95 (0.424) 111 (0.476)

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