MSGene

MSGene - Polymorphism Details

Study:

Aggelakis, 2009

Gene:

IL1B (IL-1; IL1-BETA; IL1F2)

View on AlzGene View on PDGene View on SZGene

Protein:

interleukin 1, beta (catabolin; preinterleukin 1 beta; pro-interleukin-1-beta)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011 ; ***Note that the RFLP Ava I in IL1B commonly referred to as nucleotide acid position "-511" can be assigned to two restriction sites each harboring one SNP (rs16944 and rs3087258) that both affect the restriction. Therefore this RFLP is excluded from meta-analysis.***

Total number of polymorphisms investigated by this study: 2

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs1143634 (3953T/C)	Greece	MS CTR	0.25 0.27	0.75 0.73	25 (0.071) 27 (0.072)	126 (0.359) 147 (0.392)	200 (0.570) 201 (0.536)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		n.a.-Allele	n.a.-Allele	n.a./n.a. (frequency)	n.a./n.a. (frequency)	n.a./n.a. (frequency)
Caucasian
IL1B_AvaI (rs3087258/rs16944)	Greece	MS CTR	0.37 0.36	0.63 0.64	44 (0.125) 50 (0.133)	174 (0.496) 167 (0.445)	133 (0.379) 158 (0.421)

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