MSGene

MSGene - Polymorphism Details

Study:

Mann, 2002

Gene:

IL1B (IL-1; IL1-BETA; IL1F2)

View on AlzGene View on PDGene View on SZGene

Protein:

interleukin 1, beta (catabolin; preinterleukin 1 beta; pro-interleukin-1-beta)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011 ; ***Note that the RFLP Ava I in IL1B commonly referred to as nucleotide acid position "-511" can be assigned to two restriction sites each harboring one SNP (rs16944 and rs3087258) that both affect the restriction. Therefore this RFLP is excluded from meta-analysis.***

Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs1143634 (3953T/C)	UK	MS CTR	0.26 0.26	0.74 0.74	24 (0.055) 6 (0.041)	179 (0.408) 65 (0.439)	236 (0.538) 77 (0.520)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		n.a.-Allele	n.a.-Allele	n.a./n.a. (frequency)	n.a./n.a. (frequency)	n.a./n.a. (frequency)
Caucasian
IL1B_AvaI (rs3087258/rs16944)	UK	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs1143633 (3876A/G)	UK	MS CTR	0.35 0.34	0.65 0.66	57 (0.130) 15 (0.101)	197 (0.449) 72 (0.486)	185 (0.421) 61 (0.412)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs1143627 (1903C/T)	UK	MS CTR	0.35 0.34	0.65 0.66	37 (0.087) 15 (0.109)	221 (0.518) 63 (0.460)	169 (0.396) 59 (0.431)

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