MSGene

MSGene - Polymorphism Details

Study:

Kantarci, 2003

Gene:

CTLA4 (CD; CD152; CELIAC3; CTLA-4; GSE; IDDM12)

View on SZGene

Protein:

cytotoxic T-lymphocyte-associated protein 4 (celiac disease 3; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs231775 (49A/G)	USA (Boston)	MS CTR	0.33 0.45	0.67 0.55	10 (0.105) 7 (0.189)	43 (0.453) 19 (0.514)	42 (0.442) 11 (0.297)
rs231775 (49A/G)	USA (Olmsted)	MS CTR	0.37 0.39	0.63 0.61	15 (0.125) 35 (0.149)	59 (0.492) 111 (0.472)	46 (0.383) 89 (0.379)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs5742909 (-318C/T)	USA (Olmsted)	MS CTR	0.08 0.11	0.92 0.89	1 (0.008) 4 (0.018)	16 (0.136) 41 (0.181)	101 (0.856) 182 (0.802)
rs5742909 (-318C/T)	USA (Boston)	MS CTR	0.09 0.01	0.91 0.99	1 (0.011) 0 (0.000)	15 (0.158) 1 (0.029)	79 (0.832) 34 (0.971)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs11571317 (-658C/T)	USA (Olmsted)	MS CTR	0.07 0.09	0.93 0.91	0 (0.000) 3 (0.012)	16 (0.137) 39 (0.160)	101 (0.863) 201 (0.827)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		n.a.-Allele	n.a.-Allele	n.a./n.a. (frequency)	n.a./n.a. (frequency)	n.a./n.a. (frequency)
Caucasian
CTLA4_2bpSTR-3'UTR	USA (Boston)	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)
CTLA4_2bpSTR-3'UTR	USA (Olmsted)	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs231775 (49A/G)	USA	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs5742909 (-318C/T)	USA	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		n.a.-Allele	n.a.-Allele	n.a./n.a. (frequency)	n.a./n.a. (frequency)	n.a./n.a. (frequency)
Caucasian
CTLA4_2bpSTR-3'UTR	USA	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

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