MSGene

MSGene - Polymorphism Details

Study:

de Jong, 2002

Gene:

TNF (DADB-70P7.1; DIF; TNF-alpha; TNFA; TNFSF2)

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Protein:

tumor necrosis factor (TNF superfamily, member 2) (APC1 protein; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; cachectin; tumor necrosis factor alpha)

Chromosome:

6 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 November 2011

Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs1800629 (-308G/A)	Netherlands	MS CTR	0.35 0.27	0.65 0.73	20 (0.126) 20 (0.073)	72 (0.453) 108 (0.396)	67 (0.421) 145 (0.531)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs361525 (-238A/G)	Netherlands	MS CTR	0.07 0.09	0.93 0.91	1 (0.006) 2 (0.007)	20 (0.126) 45 (0.165)	138 (0.868) 226 (0.828)

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs1800750 (-376G/A)	Netherlands	MS CTR	0.03 0.05	0.97 0.95	0 (0.000) 1 (0.004)	10 (0.063) 26 (0.095)	149 (0.937) 246 (0.901)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		n.a.-Allele	n.a.-Allele	n.a./n.a. (frequency)	n.a./n.a. (frequency)	n.a./n.a. (frequency)
Caucasian
D6S2810 (MIB)	Netherlands	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

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