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MSGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Barton, 2004
 Gene: PRKCA (AAG6; MGC129900; MGC129901; PKC-alpha; PKCA; PRKACA)   View on SZGene
 Protein: protein kinase C, alpha(aging-associated gene 6; protein kinase C alpha type)
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 35

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   m-Allele M-Allele m/m
(frequency)		 m/M
(frequency)		 M/M
(frequency)
 Caucasian
C_266713_10 UK MS
CTR		 0.24
0.23		 0.76
0.77		 8 (0.044)
22 (0.065)		 72 (0.396)
109 (0.324)		 102 (0.560)
205 (0.610)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   m-Allele M-Allele m/m
(frequency)		 m/M
(frequency)		 M/M
(frequency)
 Caucasian
C_396903_10 UK MS
CTR		 0.24
0.22		 0.76
0.78		 10 (0.056)
12 (0.036)		 65 (0.361)
121 (0.366)		 105 (0.583)
198 (0.598)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1010546 UK MS
CTR		 0.13
0.14		 0.87
0.86		 1 (0.006)
8 (0.024)		 46 (0.257)
77 (0.228)		 132 (0.737)
252 (0.748)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs11079661 UK MS
CTR		 0.17
0.20		 0.83
0.80		 3 (0.017)
11 (0.033)		 55 (0.311)
108 (0.324)		 119 (0.672)
214 (0.643)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs116187 UK MS
CTR		 0.30
0.34		 0.70
0.66		 17 (0.093)
43 (0.128)		 75 (0.410)
142 (0.421)		 91 (0.497)
152 (0.451)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs11654719 UK MS
CTR		 0.32
0.34		 0.68
0.66		 17 (0.096)
41 (0.125)		 80 (0.452)
141 (0.430)		 80 (0.452)
146 (0.445)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs11658459 UK MS
CTR		 0.41
0.36		 0.59
0.64		 33 (0.191)
50 (0.150)		 76 (0.439)
138 (0.413)		 64 (0.370)
146 (0.437)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs11867531 UK MS
CTR		 0.17
0.16		 0.83
0.84		 3 (0.017)
8 (0.025)		 53 (0.298)
85 (0.263)		 122 (0.685)
230 (0.712)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs11871468 UK MS
CTR		 0.11
0.13		 0.89
0.87		 0 (0.000)
5 (0.015)		 40 (0.219)
80 (0.239)		 143 (0.781)
250 (0.746)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs12450374 UK MS
CTR		 0.05
0.05		 0.95
0.95		 0 (0.000)
2 (0.006)		 18 (0.098)
30 (0.090)		 165 (0.902)
303 (0.904)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12451150 UK MS
CTR		 0.09
0.07		 0.91
0.93		 0 (0.000)
2 (0.006)		 31 (0.174)
42 (0.126)		 147 (0.826)
289 (0.868)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs12452012 UK MS
CTR		 0.09
0.07		 0.91
0.93		 1 (0.005)
2 (0.006)		 31 (0.170)
42 (0.125)		 150 (0.824)
293 (0.869)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12937559 UK MS
CTR		 0.15
0.17		 0.85
0.83		 11 (0.060)
13 (0.039)		 32 (0.176)
89 (0.264)		 139 (0.764)
235 (0.697)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12938937 UK MS
CTR		 0.25
0.25		 0.75
0.75		 11 (0.061)
28 (0.084)		 69 (0.383)
113 (0.337)		 100 (0.556)
194 (0.579)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs16960114 UK MS
CTR		 0.23
0.22		 0.77
0.78		 9 (0.049)
12 (0.036)		 65 (0.357)
122 (0.371)		 108 (0.593)
195 (0.593)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs17633437 UK MS
CTR		 0.40
0.37		 0.60
0.63		 31 (0.170)
43 (0.130)		 82 (0.451)
160 (0.483)		 69 (0.379)
128 (0.387)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs17710992 UK MS
CTR		 0.28
0.29		 0.72
0.71		 19 (0.104)
25 (0.074)		 66 (0.361)
144 (0.427)		 98 (0.536)
168 (0.499)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2159649 UK MS
CTR		 0.08
0.05		 0.92
0.95		 0 (0.000)
0 (0.000)		 28 (0.153)
37 (0.110)		 155 (0.847)
300 (0.890)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs228664 UK MS
CTR		 0.07
0.08		 0.93
0.92		 3 (0.016)
4 (0.012)		 20 (0.110)
47 (0.140)		 159 (0.874)
285 (0.848)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs2361485 UK MS
CTR		 0.53
0.49		 0.47
0.51		 52 (0.286)
87 (0.259)		 90 (0.495)
153 (0.455)		 40 (0.220)
96 (0.286)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs28625506 UK MS
CTR		 0.24
0.23		 0.76
0.77		 11 (0.060)
24 (0.072)		 67 (0.368)
108 (0.324)		 104 (0.571)
201 (0.604)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs34636366 UK MS
CTR		 0.12
0.15		 0.88
0.85		 6 (0.033)
3 (0.009)		 32 (0.178)
93 (0.278)		 142 (0.789)
238 (0.713)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs3764402 UK MS
CTR		 0.24
0.26		 0.76
0.74		 14 (0.077)
25 (0.075)		 61 (0.335)
121 (0.361)		 107 (0.588)
189 (0.564)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3803821 UK MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3848418 UK MS
CTR		 0.38
0.38		 0.62
0.62		 31 (0.179)
47 (0.142)		 68 (0.393)
159 (0.482)		 74 (0.428)
124 (0.376)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs4465636 UK MS
CTR		 0.34
0.36		 0.66
0.64		 17 (0.098)
34 (0.102)		 84 (0.483)
168 (0.506)		 73 (0.420)
130 (0.392)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4790904 UK MS
CTR		 0.19
0.22		 0.81
0.78		 6 (0.033)
18 (0.054)		 57 (0.313)
109 (0.329)		 119 (0.654)
204 (0.616)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs7210446 UK MS
CTR		 0.43
0.40		 0.57
0.60		 39 (0.214)
62 (0.186)		 80 (0.440)
144 (0.432)		 63 (0.346)
127 (0.381)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs721429 UK MS
CTR		 0.43
0.43		 0.57
0.57		 35 (0.194)
58 (0.173)		 85 (0.472)
173 (0.516)		 60 (0.333)
104 (0.310)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7342847 UK MS
CTR		 0.35
0.39		 0.65
0.61		 27 (0.152)
40 (0.119)		 72 (0.404)
180 (0.536)		 79 (0.444)
116 (0.345)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs759117 UK MS
CTR		 0.40
0.42		 0.60
0.58		 27 (0.165)
56 (0.167)		 78 (0.476)
170 (0.507)		 59 (0.360)
109 (0.325)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs8069454 UK MS
CTR		 0.14
0.19		 0.86
0.81		 2 (0.011)
14 (0.042)		 48 (0.261)
98 (0.291)		 134 (0.728)
225 (0.668)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs8074995 UK MS
CTR		 0.13
0.15		 0.87
0.85		 8 (0.044)
5 (0.015)		 32 (0.176)
92 (0.275)		 142 (0.780)
238 (0.710)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs8075066 UK MS
CTR		 0.26
0.29		 0.74
0.71		 13 (0.071)
24 (0.072)		 68 (0.372)
144 (0.430)		 102 (0.557)
167 (0.499)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs9895770 UK MS
CTR		 0.24
0.22		 0.76
0.78		 9 (0.050)
14 (0.043)		 68 (0.380)
115 (0.350)		 102 (0.570)
200 (0.608)
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Top Results Details
1. HLA-DRB1
2. IL2RA
3. IL7R
4. TAGAP
5. CLEC16A
6. EVI5
7. GWA_16q24.1
8. GWA_5p13.1
9. TTC34
10. AHI1   
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Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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