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MSGene - Polymorphism Details
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 Study: Barcellos, 2004
 Gene: NOS2 (HEP-NOS; INOS; NOS; NOS2A)   View on AlzGene   View on PDGene
 Protein: nitric oxide synthase 2, inducible(NOS, type II; nitric oxide synthase 2A; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase, macrophage)
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 June 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 African Descent
rs1137933 (D346D) USA MS
CTR
0.20
0.16
0.80
0.84
18 (0.041)
7 (0.024)
143 (0.324)
79 (0.270)
281 (0.636)
207 (0.706)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 African Descent
rs1137933 (D346D) USA MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
 Caucasian
rs1137933 (D346D) Overlaps with Motsinger, 2007 (CC) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs1137933 (D346D) Overlaps with Motsinger, 2007 (CC) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   TAAA-Allele del-Allele TAAA/TAAA
(frequency)
TAAA/del
(frequency)
del/del
(frequency)
 Caucasian
rs12720460 (4bp-indel) USA (multiplex) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs12720460 (4bp-indel) USA (simplex) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   n.a.-Allele n.a.-Allele n.a./n.a.
(frequency)
n.a./n.a.
(frequency)
n.a./n.a.
(frequency)
 Caucasian
NOS2_5bpSTR-prom (CCTTTn) USA (multiplex) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
NOS2_5bpSTR-prom (CCTTTn) USA (simplex) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
NOS2_S569L USA (multiplex) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
NOS2_S569L USA (simplex) MS
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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