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MSGene - Polymorphism Details
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 Study: Miterski, 2002
 Gene: NFKBIA (IKBA; MAD-3; NFKBI)   View on AlzGene
 Protein: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha(IkappaBalpha; nuclear factor of kappa light chain gene enhancer in B-cells)
 Chromosome: 14   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 7 April 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 10

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   2-Allele 1-Allele 2/2
(frequency)		 2/1
(frequency)		 1/1
(frequency)
 Caucasian
NFKBIA _-1169A/G Germany MS
CTR		 0.25
0.27		 0.75
0.73		 17 (0.062)
31 (0.073)		 103 (0.377)
168 (0.393)		 153 (0.560)
228 (0.534)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   2-Allele 1-Allele 2/2
(frequency)		 2/1
(frequency)		 1/1
(frequency)
 Caucasian
NFKBIA_-1001A/G Germany MS
CTR		 0.26
0.27		 0.74
0.73		 20 (0.069)
31 (0.073)		 111 (0.384)
168 (0.393)		 158 (0.547)
228 (0.534)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   2-Allele 1-Allele 2/2
(frequency)		 2/1
(frequency)		 1/1
(frequency)
 Caucasian
NFKBIA_-1256C/T Germany MS
CTR		 0.05
0.05		 0.95
0.95		 1 (0.004)
1 (0.002)		 26 (0.095)
41 (0.096)		 246 (0.901)
385 (0.902)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   2-Allele 1-Allele 2/2
(frequency)		 2/1
(frequency)		 1/1
(frequency)
 Caucasian
NFKBIA_-420C/T Germany MS
CTR		 0.19
0.22		 0.81
0.78		 16 (0.037)
19 (0.051)		 133 (0.305)
131 (0.348)		 287 (0.658)
226 (0.601)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   2-Allele 1-Allele 2/2
(frequency)		 2/1
(frequency)		 1/1
(frequency)
 Caucasian
NFKBIA_-708ins8 Germany MS
CTR		 0.26
0.28		 0.74
0.72		 20 (0.066)
24 (0.080)		 117 (0.384)
122 (0.408)		 168 (0.551)
153 (0.512)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   2-Allele 1-Allele 2/2
(frequency)		 2/1
(frequency)		 1/1
(frequency)
 Caucasian
NFKBIA_Ex6-3'-T2C Germany MS
CTR		 0.40
0.38		 0.60
0.62		 60 (0.162)
49 (0.140)		 178 (0.480)
164 (0.470)		 133 (0.358)
136 (0.390)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1050851 (A102A) Germany MS
CTR		 0.19
0.18		 0.81
0.82		 3 (0.041)
2 (0.029)		 22 (0.301)
21 (0.300)		 48 (0.658)
47 (0.671)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1957106 (D27D) Germany MS
CTR		 0.34
0.32		 0.66
0.68		 38 (0.117)
33 (0.102)		 146 (0.448)
141 (0.438)		 142 (0.436)
148 (0.460)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2233417 (G262A) Germany MS
CTR		 0.15
0.19		 0.85
0.81		 2 (0.026)
3 (0.039)		 19 (0.247)
24 (0.312)		 56 (0.727)
50 (0.649)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs3138054 (G49A) Germany MS
CTR		 0.11
0.15		 0.89
0.85		 1 (0.014)
2 (0.029)		 14 (0.200)
17 (0.246)		 55 (0.786)
50 (0.725)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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