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MSGene - Polymorphism Details
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 Study: Kantarci, 2008
 Gene: IFNG (IFG; IFI)   View on AlzGene   View on PDGene   View on SZGene
 Protein: interferon, gamma
 Chromosome: 12   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 15

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   n.a.-Allele n.a.-Allele n.a./n.a.
(frequency)		 n.a./n.a.
(frequency)		 n.a./n.a.
(frequency)
 Caucasian
D12S313 Belgium MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
D12S313 UK (Northern Ireland) MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
D12S313 USA MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   n.a.-Allele n.a.-Allele n.a./n.a.
(frequency)		 n.a./n.a.
(frequency)		 n.a./n.a.
(frequency)
 Caucasian
IFNG_2bpSTR (intron1) Belgium MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
IFNG_2bpSTR (intron1) UK (Northern Ireland) MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
IFNG_2bpSTR (intron1) USA MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs10878766 Belgium MS
CTR		 0.49
0.53		 0.51
0.47		 46 (0.222)
55 (0.281)		 111 (0.536)
97 (0.495)		 50 (0.242)
44 (0.224)
rs10878766 UK (Northern Ireland) MS
CTR		 0.50
0.48		 0.50
0.52		 96 (0.229)
46 (0.232)		 224 (0.533)
98 (0.495)		 100 (0.238)
54 (0.273)
rs10878766 USA MS
CTR		 0.41
0.46		 0.59
0.54		 40 (0.186)
86 (0.198)		 97 (0.451)
230 (0.530)		 78 (0.363)
118 (0.272)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1118866 Belgium MS
CTR		 0.27
0.26		 0.73
0.74		 20 (0.097)
13 (0.066)		 73 (0.354)
77 (0.393)		 113 (0.549)
106 (0.541)
rs1118866 UK (Northern Ireland) MS
CTR		 0.32
0.34		 0.68
0.66		 40 (0.097)
20 (0.102)		 183 (0.444)
95 (0.482)		 189 (0.459)
82 (0.416)
rs1118866 USA MS
CTR		 0.33
0.29		 0.67
0.71		 25 (0.117)
34 (0.079)		 91 (0.425)
187 (0.432)		 98 (0.458)
212 (0.490)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1861494 Belgium MS
CTR		 0.25
0.26		 0.75
0.74		 20 (0.098)
12 (0.063)		 64 (0.312)
74 (0.389)		 121 (0.590)
104 (0.547)
rs1861494 UK (Northern Ireland) MS
CTR		 0.31
0.36		 0.69
0.64		 43 (0.106)
20 (0.105)		 169 (0.417)
95 (0.500)		 193 (0.477)
75 (0.395)
rs1861494 USA MS
CTR		 0.32
0.29		 0.68
0.71		 24 (0.112)
32 (0.074)		 89 (0.414)
191 (0.441)		 102 (0.474)
210 (0.485)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2069705 Belgium MS
CTR		 0.31
0.28		 0.69
0.72		 17 (0.084)
15 (0.078)		 90 (0.446)
77 (0.401)		 95 (0.470)
100 (0.521)
rs2069705 UK (Northern Ireland) MS
CTR		 0.37
0.37		 0.63
0.63		 50 (0.120)
24 (0.119)		 204 (0.492)
99 (0.493)		 161 (0.388)
78 (0.388)
rs2069705 USA MS
CTR		 0.35
0.35		 0.65
0.65		 27 (0.123)
47 (0.107)		 100 (0.457)
210 (0.477)		 92 (0.420)
183 (0.416)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2069716 Belgium MS
CTR		 0.04
0.06		 0.96
0.94		 0 (0.000)
0 (0.000)		 16 (0.078)
23 (0.117)		 189 (0.922)
173 (0.883)
rs2069716 UK (Northern Ireland) MS
CTR		 0.06
0.04		 0.94
0.96		 0 (0.000)
0 (0.000)		 49 (0.116)
15 (0.073)		 375 (0.884)
190 (0.927)
rs2069716 USA MS
CTR		 0.05
0.05		 0.95
0.95		 0 (0.000)
0 (0.000)		 22 (0.105)
46 (0.107)		 187 (0.895)
384 (0.893)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2069727 (3'325G/A) Belgium MS
CTR		 0.46
0.51		 0.54
0.49		 36 (0.176)
50 (0.260)		 114 (0.559)
96 (0.500)		 54 (0.265)
46 (0.240)
rs2069727 (3'325G/A) UK (Northern Ireland) MS
CTR		 0.47
0.48		 0.53
0.52		 85 (0.198)
45 (0.222)		 236 (0.550)
105 (0.517)		 108 (0.252)
53 (0.261)
rs2069727 (3'325G/A) USA MS
CTR		 0.38
0.45		 0.62
0.55		 38 (0.172)
87 (0.197)		 90 (0.407)
227 (0.515)		 93 (0.421)
127 (0.288)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2216164 Belgium MS
CTR		 0.37
0.29		 0.63
0.71		 29 (0.141)
18 (0.092)		 93 (0.454)
76 (0.388)		 83 (0.405)
102 (0.520)
rs2216164 UK (Northern Ireland) MS
CTR		 0.43
0.42		 0.57
0.58		 70 (0.166)
32 (0.161)		 220 (0.521)
103 (0.518)		 132 (0.313)
64 (0.322)
rs2216164 USA MS
CTR		 0.43
0.42		 0.58
0.58		 37 (0.168)
77 (0.175)		 113 (0.514)
219 (0.497)		 70 (0.318)
145 (0.329)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2216165 Belgium MS
CTR		 0.06
0.03		 0.94
0.97		 1 (0.005)
1 (0.005)		 23 (0.113)
9 (0.046)		 180 (0.882)
186 (0.949)
rs2216165 UK (Northern Ireland) MS
CTR		 0.06
0.06		 0.94
0.94		 9 (0.021)
2 (0.010)		 36 (0.085)
21 (0.103)		 378 (0.894)
180 (0.887)
rs2216165 USA MS
CTR		 0.06
0.06		 0.94
0.94		 0 (0.000)
3 (0.007)		 25 (0.116)
47 (0.109)		 190 (0.884)
383 (0.885)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2430561 Belgium MS
CTR		 0.46
0.50		 0.54
0.50		 33 (0.172)
41 (0.217)		 112 (0.583)
106 (0.561)		 47 (0.245)
42 (0.222)
rs2430561 UK (Northern Ireland) MS
CTR		 0.47
0.48		 0.53
0.52		 74 (0.189)
44 (0.230)		 217 (0.555)
95 (0.497)		 100 (0.256)
52 (0.272)
rs2430561 USA MS
CTR		 0.40
0.45		 0.60
0.55		 38 (0.180)
81 (0.191)		 92 (0.436)
218 (0.513)		 81 (0.384)
126 (0.296)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2870957 Belgium MS
CTR		 0.19
0.24		 0.81
0.76		 7 (0.034)
7 (0.036)		 65 (0.320)
81 (0.418)		 131 (0.645)
106 (0.546)
rs2870957 UK (Northern Ireland) MS
CTR		 0.22
0.25		 0.78
0.75		 30 (0.071)
8 (0.040)		 128 (0.304)
83 (0.411)		 263 (0.625)
111 (0.550)
rs2870957 USA MS
CTR		 0.22
0.22		 0.78
0.78		 15 (0.068)
21 (0.048)		 65 (0.297)
147 (0.336)		 139 (0.635)
270 (0.616)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs3181034 Belgium MS
CTR		 0.27
0.27		 0.73
0.73		 15 (0.073)
14 (0.071)		 80 (0.388)
76 (0.388)		 111 (0.539)
106 (0.541)
rs3181034 UK (Northern Ireland) MS
CTR		 0.31
0.30		 0.69
0.70		 35 (0.082)
15 (0.075)		 195 (0.458)
91 (0.455)		 196 (0.460)
94 (0.470)
rs3181034 USA MS
CTR		 0.32
0.30		 0.68
0.70		 22 (0.103)
35 (0.081)		 93 (0.435)
187 (0.431)		 99 (0.463)
212 (0.488)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs7135373 Belgium MS
CTR		 0.26
0.27		 0.74
0.73		 19 (0.094)
13 (0.067)		 69 (0.340)
79 (0.405)		 115 (0.567)
103 (0.528)
rs7135373 UK (Northern Ireland) MS
CTR		 0.33
0.34		 0.67
0.66		 37 (0.096)
18 (0.091)		 179 (0.466)
97 (0.492)		 168 (0.438)
82 (0.416)
rs7135373 USA MS
CTR		 0.34
0.30		 0.66
0.70		 21 (0.097)
31 (0.071)		 104 (0.479)
200 (0.460)		 92 (0.424)
204 (0.469)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs7954499 Belgium MS
CTR		 0.47
0.52		 0.53
0.48		 40 (0.194)
53 (0.272)		 114 (0.553)
96 (0.492)		 52 (0.252)
46 (0.236)
rs7954499 UK (Northern Ireland) MS
CTR		 0.47
0.47		 0.53
0.53		 83 (0.201)
41 (0.207)		 219 (0.532)
103 (0.520)		 110 (0.267)
54 (0.273)
rs7954499 USA MS
CTR		 0.38
0.45		 0.62
0.55		 30 (0.138)
76 (0.175)		 107 (0.491)
237 (0.545)		 81 (0.372)
122 (0.280)
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MSGene Top Results
Top Results Details
1. HLA-DRB1
2. IL2RA
3. IL7R
4. TAGAP
5. CLEC16A
6. EVI5
7. GWA_16q24.1
8. GWA_5p13.1
9. TTC34
10. AHI1   
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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