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MSGene - Polymorphism Details

Study:

Sundqvist, 2010

Gene:

CYP27B1 (CP2B; CYP1; CYP1alpha; CYP27B; P450c1; PDDR; VDD1; VDDR; VDDRI)

Protein:

cytochrome P450, family 27, subfamily B, polypeptide 1 (1alpha(OH)ase; 25 hydroxyvitamin D3-1-alpha hydroxylase; 25-Hydroxyvitamin D3 1alpha-hydroxylase; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D-1-alpha-hydroxylase; P450C1-alpha; P450VD1-alpha; VD3 1A hydroxylase; VDDR I; calcidiol 1-monooxygenase; cytochrome P450, subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase), polypeptide 1; cytochrome P450, subfamily XXVIIB, polypeptide 1)

Chromosome:

12 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Total number of polymorphisms investigated by this study: 7

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs4646536	Sweden	MS CTR	0.32 0.35	0.68 0.65	217 (0.105) 215 (0.124)	904 (0.438) 791 (0.456)	943 (0.457) 728 (0.420)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		T-Allele	G-Allele	T/T (frequency)	T/G (frequency)	G/G (frequency)
Caucasian
rs10877012	Sweden	MS CTR	0.33 0.35	0.67 0.65	210 (0.106) 211 (0.125)	867 (0.439) 769 (0.457)	896 (0.454) 702 (0.417)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs1048691	Sweden	MS CTR	0.22 0.23	0.78 0.77	96 (0.050) 88 (0.051)	669 (0.345) 602 (0.350)	1173 (0.605) 1032 (0.599)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs10877015	Sweden	MS CTR	0.32 0.35	0.68 0.65	215 (0.103) 217 (0.125)	909 (0.436) 795 (0.457)	962 (0.461) 729 (0.419)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		G-Allele	T-Allele	G/G (frequency)	G/T (frequency)	T/T (frequency)
Caucasian
rs4646537	Sweden	MS CTR	0.04 0.04	0.96 0.96	3 (0.001) 3 (0.002)	151 (0.073) 135 (0.078)	1918 (0.926) 1585 (0.920)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs703842i	Sweden	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs8176345	Sweden	MS CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

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Top Results Details

1.	HLA-DRB1
2.	IL2RA
3.	IL7R
4.	TAGAP
5.	CLEC16A
6.	EVI5
7.	GWA_16q24.1
8.	GWA_5p13.1
9.	TTC34
10.	AHI1 [see more] [close]

MSGene Stats

Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324

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