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MSGene - Polymorphism Details
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 Study: Kristjansdottir, 2008
 Gene: IRF5 (SLEB10)
 Protein: interferon regulatory factor 5
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 10

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   ins-Allele del-Allele ins/ins
(frequency)		 ins/del
(frequency)		 del/del
(frequency)
 Caucasian
IRF5_indel (-/CGGGG) Spain MS
CTR		 0.53
0.48		 0.47
0.52		 183 (0.281)
184 (0.231)		 324 (0.498)
398 (0.499)		 144 (0.221)
216 (0.271)
IRF5_indel (-/CGGGG) Sweden MS
CTR		 0.49
0.45		 0.51
0.55		 260 (0.240)
239 (0.202)		 542 (0.500)
585 (0.495)		 282 (0.260)
358 (0.303)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs10954213 Spain MS
CTR		 0.31
0.35		 0.69
0.65		 62 (0.095)
98 (0.123)		 279 (0.429)
362 (0.454)		 309 (0.475)
337 (0.423)
rs10954213 Sweden MS
CTR		 0.33
0.36		 0.67
0.64		 118 (0.109)
153 (0.129)		 479 (0.442)
545 (0.461)		 487 (0.449)
484 (0.409)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11770589 Spain MS
CTR		 0.43
0.45		 0.57
0.55		 120 (0.185)
161 (0.202)		 319 (0.491)
395 (0.496)		 211 (0.325)
241 (0.302)
rs11770589 Sweden MS
CTR		 0.49
0.50		 0.51
0.50		 260 (0.240)
296 (0.250)		 542 (0.500)
591 (0.500)		 282 (0.260)
296 (0.250)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12539741 Spain MS
CTR		 0.11
0.09		 0.89
0.91		 8 (0.012)
6 (0.008)		 127 (0.195)
131 (0.164)		 515 (0.792)
660 (0.828)
rs12539741 Sweden MS
CTR		 0.15
0.14		 0.85
0.86		 24 (0.022)
23 (0.019)		 277 (0.256)
285 (0.241)		 783 (0.722)
874 (0.739)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2004640 Spain MS
CTR		 0.41
0.47		 0.59
0.53		 109 (0.168)
176 (0.221)		 315 (0.485)
397 (0.498)		 226 (0.348)
224 (0.281)
rs2004640 Sweden MS
CTR		 0.45
0.48		 0.55
0.52		 220 (0.203)
272 (0.230)		 536 (0.494)
590 (0.499)		 328 (0.303)
320 (0.271)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2280714 Spain MS
CTR		 0.27
0.32		 0.73
0.68		 47 (0.072)
82 (0.103)		 256 (0.394)
347 (0.435)		 346 (0.533)
369 (0.462)
rs2280714 Sweden MS
CTR		 0.29
0.30		 0.71
0.70		 91 (0.084)
106 (0.090)		 447 (0.412)
497 (0.420)		 546 (0.504)
579 (0.490)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs3757385 Spain MS
CTR		 0.30
0.35		 0.70
0.65		 59 (0.091)
98 (0.123)		 272 (0.418)
362 (0.454)		 319 (0.491)
337 (0.423)
rs3757385 Sweden MS
CTR		 0.33
0.34		 0.67
0.66		 118 (0.109)
137 (0.116)		 479 (0.442)
530 (0.448)		 487 (0.449)
515 (0.436)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3807306 Spain MS
CTR		 0.43
0.48		 0.57
0.52		 120 (0.185)
184 (0.231)		 319 (0.491)
397 (0.498)		 211 (0.325)
216 (0.271)
rs3807306 Sweden MS
CTR		 0.46
0.49		 0.54
0.51		 229 (0.211)
284 (0.240)		 539 (0.497)
591 (0.500)		 316 (0.292)
307 (0.260)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4728142 Spain MS
CTR		 0.52
0.46		 0.48
0.54		 176 (0.271)
169 (0.212)		 324 (0.498)
396 (0.497)		 150 (0.231)
232 (0.291)
rs4728142 Sweden MS
CTR		 0.48
0.44		 0.52
0.56		 250 (0.231)
229 (0.194)		 541 (0.499)
582 (0.492)		 293 (0.270)
371 (0.314)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs729302 Spain MS
CTR		 0.30
0.32		 0.70
0.68		 59 (0.091)
82 (0.103)		 272 (0.418)
346 (0.434)		 319 (0.491)
369 (0.463)
rs729302 Sweden MS
CTR		 0.33
0.34		 0.67
0.66		 118 (0.109)
137 (0.116)		 479 (0.442)
530 (0.448)		 487 (0.449)
515 (0.436)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   ins-Allele del-Allele ins/ins
(frequency)		 ins/del
(frequency)		 del/del
(frequency)
 Caucasian
IRF5_indel (-/CGGGG) Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs10954213 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11770589 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12539741 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2004640 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2280714 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs3757385 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3807306 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4728142 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs729302 Finland MS
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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