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MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs4680534
Polymorphism:
rs4680534
Gene:
IL12A
(CLMF; IL-12A; NFSK; NKSF1; P35)
View on SZGene
Protein:
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
(CLMF p35; IL-12 subunit p35; IL-12, subunit p35; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; OTTHUMP00000213704; OTTHUMP00000213705; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12, p35; interleukin-12 alpha chain; interleukin-12 subunit alpha; natural killer cell stimulatory factor 1, 35 kD subunit)
Chromosome:
3
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 25 November 2011
Polymorphism:
rs2243123
rs4680534 (significant)
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
Alleles
Genotypes
# Case-Control
Samples
C-Allele
(frequency)
T-Allele
(frequency)
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
8
MS
CTR
0.36
0.34
0.64
0.66
1064 (0.132)
892 (0.115)
3725 (0.461)
3478 (0.447)
3295 (0.408)
3408 (0.438)
Other/Mixed
1
MS
CTR
0.12
0.18
0.88
0.82
3 (0.015)
6 (0.031)
41 (0.208)
58 (0.296)
153 (0.777)
132 (0.673)
Total
9
MS
CTR
0.36
0.33
0.64
0.67
1067 (0.129)
898 (0.113)
3766 (0.455)
3536 (0.443)
3448 (0.416)
3540 (0.444)
Meta-Analysis Methods
* New *
Cumulative Meta-analysis
2) Forest plot for polymorphism
rs4680534
Please also
see disclaimer
for more information on these meta-analyses.
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STAT3
MSGene Top Results
Top Results Details
1.
HLA-DRB1
2.
IL2RA
3.
IL7R
4.
TAGAP
5.
CLEC16A
6.
EVI5
7.
GWA_16q24.1
8.
GWA_5p13.1
9.
TTC34
10.
AHI1
[see more]
[close]
11.
GWA_3q24
12.
CD226
13.
CD5
14.
IL12B
15.
PLEK
16.
IL22RA2
17.
NCOA5
18.
STAT3
19.
GWA_2p21
20.
DKKL1
21.
CYP24A1
22.
TNFRSF1A
23.
TNFSF14
24.
CD86
25.
CD58
26.
GWA_3q12.3
27.
SH2B3
28.
SP140
29.
GPR65
30.
CYP27B1
31.
CD40
32.
MAPK1
33.
ZFP36L1
34.
AGAP2
35.
RPS6KB1
36.
SOX8
37.
MPV17L2
38.
PTPRK
39.
ZMIZ1
40.
PVR
41.
HHEX
42.
C1orf106
43.
PKIA
44.
BACH2
45.
MMEL1
46.
SLC30A7
47.
BATF
48.
KIF21B
49.
SAE1
50.
DLEU1
51.
MYC
52.
SYK
53.
RGS14
54.
DDAH1
55.
MERTK
56.
ZNF767
57.
CLECL1
58.
MANBA
59.
TYK2
60.
ZBTB46
61.
CDC37
62.
NDFIP1
63.
MAP3K14
64.
RGS1
65.
TMEM39A
66.
MALT1
67.
CARD11
68.
MAF
69.
IRF5
MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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An up-to-date collection of all published genetic association studies.
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