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MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs2234693
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 Polymorphism: rs2234693 (PvuII)
 Gene: ESR1  (RP1-130E4.1; DKFZp686N23123; ER; ESR; ESRA; Era; NR3A1)  Entrez Gene    View on AlzGene   View on PDGene   View on SZGene
 Protein: estrogen receptor 1  (ER-alpha; estradiol receptor; estrogen receptor; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 4 +49 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; nuclear receptor subfamily 3 group A member 1)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 23 November 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  C-Allele
(frequency)
T-Allele
(frequency)
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian 3 MS
CTR
0.45
0.45
0.55
0.55
70 (0.206)
71 (0.209)
164 (0.484)
166 (0.490)
105 (0.310)
102 (0.301)
 Asian 1 MS
CTR
0.53
0.37
0.47
0.63
27 (0.233)
14 (0.139)
68 (0.586)
47 (0.465)
21 (0.181)
40 (0.396)
Total 4 MS
CTR
0.47
0.44
0.53
0.57
97 (0.213)
85 (0.193)
232 (0.510)
213 (0.484)
126 (0.277)
142 (0.323)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs2234693 (PvuII)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs79626648 (594A/G-BtgI)
rs9340799 (XbaI)

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Top Results Details
1. HLA-DRB1
2. IL2RA
3. IL7R
4. TAGAP
5. CLEC16A
6. EVI5
7. GWA_16q24.1
8. GWA_5p13.1
9. TTC34
10. AHI1   
[see more]
MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
ALSGene
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An up-to-date collection of all published genetic association studies.
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