MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs909253

Polymorphism:

rs909253 (NcoI)

Gene:

LTA (DAMA-25N12.13; LT; TNFB; TNFSF1)

View on ALSGene View on AlzGene View on SZGene

Protein:

lymphotoxin alpha (TNF superfamily, member 1) (OTTHUMP00000165897; lymphotoxin alpha; tumor necrosis factor beta)

Chromosome:

6 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 30 January 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		A-Allele (frequency)	G-Allele (frequency)	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian	3	MS CTR	0.26 0.36	0.74 0.64	17 (0.072) 29 (0.107)	89 (0.379) 136 (0.500)	129 (0.549) 107 (0.393)
Other/Mixed	1	MS CTR	0.30 0.28	0.70 0.72	25 (0.092) 40 (0.074)	112 (0.413) 223 (0.411)	134 (0.494) 279 (0.515)
Total	4	MS CTR	0.28 0.31	0.72 0.70	42 (0.083) 69 (0.085)	201 (0.397) 359 (0.441)	263 (0.520) 386 (0.474)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs909253 (NcoI)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

LTA_319C/G
LTA_N26T
TNFa (D6S2792)
TNFb
TNFc

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