MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs1800470

Polymorphism:

rs1800470 (L10P)

Gene:

TGFB1 (CED; DPD1; TGFB; TGFbeta) View on AlzGene View on PDGene

Protein:

transforming growth factor, beta 1(TGF-beta 1 protein; diaphyseal dysplasia 1, progressive; transforming growth factor-beta 1)

Chromosome:

19 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 31 January 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		C-Allele (frequency)	T-Allele (frequency)	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian	3	MS CTR	0.42 0.37	0.58 0.63	82 (0.195) 73 (0.140)	188 (0.447) 242 (0.463)	151 (0.359) 208 (0.398)
Other/Mixed	1	MS CTR	0.43 0.52	0.57 0.48	18 (0.184) 25 (0.275)	48 (0.490) 45 (0.495)	32 (0.327) 21 (0.231)
Total	4	MS CTR	0.42 0.39	0.58 0.61	100 (0.193) 98 (0.160)	236 (0.455) 287 (0.467)	183 (0.353) 229 (0.373)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs1800470 (L10P)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs1800468 (-800G/A)
rs1800469 (-509C/T)
rs1800472 (T263I)
rs9282871 (L10P)
TGFB1_72indel
TGFB1_78indel

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