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MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs1800682
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 Polymorphism: rs1800682 (-670A/G-MvaI)
 Gene: FAS (ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6)   View on AlzGene
 Protein: Fas (TNF receptor superfamily, member 6)(APO-1 cell surface antigen; CD95 antigen; Fas AMA; Fas antigen; apoptosis antigen 1; tumor necrosis factor receptor superfamily, member 6)
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  G-Allele
(frequency)
A-Allele
(frequency)
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian 4 MS
CTR
0.45
0.47
0.55
0.53
207 (0.198)
212 (0.202)
528 (0.505)
562 (0.536)
310 (0.297)
274 (0.261)
 Asian 1 MS
CTR
0.49
0.47
0.51
0.53
23 (0.202)
25 (0.207)
65 (0.570)
63 (0.521)
26 (0.228)
33 (0.273)
 Other/Mixed 1 MS
CTR
0.38
0.38
0.62
0.62
22 (0.206)
18 (0.161)
37 (0.346)
50 (0.446)
48 (0.449)
44 (0.393)
Total 6 MS
CTR
0.45
0.46
0.55
0.54
252 (0.199)
255 (0.199)
630 (0.498)
675 (0.527)
384 (0.303)
351 (0.274)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs1800682 (-670A/G-MvaI)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

FAS_416A/G
FAS_735T/C (MaeI)
FAS_836C/T
rs3218612 (26A/G)

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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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