MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs2070874

Polymorphism:

rs2070874 (33C/T)

Gene:

IL4 (BCGF-1; BCGF1; BSF1; IL-4; MGC79402) View on AlzGene View on PDGene View on SZGene

Protein:

interleukin 4(B cell growth factor 1; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1)

Chromosome:

5 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		T-Allele (frequency)	C-Allele (frequency)	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian	5	MS CTR	0.15 0.17	0.85 0.83	41 (0.026) 39 (0.030)	402 (0.253) 354 (0.274)	1149 (0.722) 900 (0.696)
African Descent	1	MS CTR	0.31 0.25	0.69 0.76	5 (0.091) 3 (0.064)	24 (0.436) 17 (0.362)	26 (0.473) 27 (0.574)
Other/Mixed	2	MS CTR	0.19 0.21	0.81 0.79	8 (0.049) 6 (0.016)	46 (0.284) 146 (0.383)	108 (0.667) 229 (0.601)
Total	8	MS CTR	0.16 0.18	0.84 0.82	54 (0.030) 48 (0.028)	472 (0.261) 517 (0.300)	1283 (0.709) 1156 (0.672)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs2070874 (33C/T)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

IL4_-1098T/G
IL4_2580C/A
IL4_2bpSTR (intron 3)
IL4_-523C/T
IL4_STR (intragenic)
rs2243248
rs2243250 (-589C/T)

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