MSGene

MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs4754

Polymorphism:

rs4754 (327T/C)

Gene:

SPP1 (BNSP; BSPI; ETA-1; MGC110940; OPN)

View on SZGene

Protein:

secreted phosphoprotein 1 (SPP1/CALPHA1 fusion; bone sialoprotein I; early T-lymphocyte activation 1; osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein-1 (osteopontin, bone sialoprotein))

Chromosome:

4 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		C-Allele (frequency)	T-Allele (frequency)	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian	3	MS CTR	0.30 0.28	0.70 0.72	152 (0.086) 109 (0.085)	749 (0.425) 503 (0.394)	860 (0.488) 664 (0.520)
Asian	1	MS CTR	0.85 0.69	0.15 0.31	90 (0.776) 60 (0.484)	18 (0.155) 52 (0.419)	8 (0.069) 12 (0.097)
Total	4	MS CTR	0.33 0.32	0.67 0.68	242 (0.129) 169 (0.121)	767 (0.409) 555 (0.396)	868 (0.462) 676 (0.483)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs4754 (327T/C)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs9138 (1284A/C)

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