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MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs4754
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 Polymorphism: rs4754 (327T/C)
 Gene: SPP1  (BNSP; BSPI; ETA-1; MGC110940; OPN)  Entrez Gene    View on SZGene
 Protein: secreted phosphoprotein 1  (SPP1/CALPHA1 fusion; bone sialoprotein I; early T-lymphocyte activation 1; osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein-1 (osteopontin, bone sialoprotein))  ProteinLink
 Chromosome: 4   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  C-Allele
(frequency)
T-Allele
(frequency)
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian 3 MS
CTR
0.30
0.28
0.70
0.72
152 (0.086)
109 (0.085)
749 (0.425)
503 (0.394)
860 (0.488)
664 (0.520)
 Asian 1 MS
CTR
0.85
0.69
0.15
0.31
90 (0.776)
60 (0.484)
18 (0.155)
52 (0.419)
8 (0.069)
12 (0.097)
Total 4 MS
CTR
0.33
0.32
0.67
0.68
242 (0.129)
169 (0.121)
767 (0.409)
555 (0.396)
868 (0.462)
676 (0.483)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs4754 (327T/C)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs9138 (1284A/C)

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Top Results Details
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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