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MSGene - Meta-Analysis of All Published MS Association Studies (Case-Control Only) rs7041
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 Polymorphism: rs7041 (D416E)
 Gene: GC  (DBP; DBP/GC; VDBG; VDBP)  Entrez Gene    View on AlzGene   View on SZGene
 Protein: group-specific component (vitamin D binding protein)  (vitamin D binding protein; vitamin D-binding alpha-globulin; vitamin D-binding protein; vitamin D-binding protein/group specific component)  ProteinLink
 Chromosome: 4   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  T-Allele
(frequency)
G-Allele
(frequency)
T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
 Caucasian 2 MS
CTR
0.43
0.44
0.57
0.56
35 (0.179)
64 (0.196)
99 (0.508)
161 (0.492)
61 (0.313)
102 (0.312)
 Asian 1 MS
CTR
0.82
0.78
0.18
0.22
72 (0.673)
67 (0.615)
31 (0.290)
36 (0.330)
4 (0.037)
6 (0.055)
Total 3 MS
CTR
0.57
0.53
0.43
0.47
107 (0.354)
131 (0.300)
130 (0.430)
197 (0.452)
65 (0.215)
108 (0.248)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs7041 (D416E)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs2282679
rs4588 (T420K)

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MSGene Recent Updates
MSGene Top Results
Top Results Details
1. HLA-DRB1
2. IL2RA
3. IL7R
4. TAGAP
5. CLEC16A
6. EVI5
7. GWA_16q24.1
8. GWA_5p13.1
9. TTC34
10. AHI1   
[see more]
MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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An up-to-date collection of all published genetic association studies.
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